Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey
Yu, Yan-Qin1,2; Ma, Li3; Wang, Wen-Jun4; Zhao, Yu-Qian5; Xu, Hui-Fang6; Cao, Ji7,8; Li, Li9; Hao, Jin-Qi2; Gao, Jing-Ru2; Gu, Xiao-Fen10; Liu, Yun-Yong11; Huang, Juan-Xiu12; Fan, Yan-Ping13; Du, Ling-Bin14; Cao, He-Lu15; Feng, Chang-Yan16; Zhu, Qian17; Wang, Xiao-Hui18; Du, Jing-Chang19; Bangura, Mohamed S.3; Zhang, Xi20; Zhang, Shao-Kai6; Qiao, You-Lin1,6,21
Corresponding AuthorZhang, Xi(zhangxipkuch@163.com) ; Zhang, Shao-Kai(shaokaizhang@126.com) ; Qiao, You-Lin(qiaoy@cicams.ac.cn)
AbstractBackground: Colorectal cancer (CRC) is one of the most common cancers in China, and most CRC patients have already reached an advanced stage by the time of initial diagnosis. Due to the loss of health as a result of cancer, it has consequence on the treatment which may affect the psychophysical and social impairment of CRC patients. These indicators (psychophysical, function and social impairment) affect the health-related quality of life (HRQOL). There are limited studies that focus on advanced CRC patients in China. This study aimed to assess the HRQOL and its associated factors of advanced CRC patients in China. Methods: This was a cross-sectional, nationwide, hospital-based, and multi-center survey. According to the traditional administrative district definition, we selected 19 hospitals in 7 regions by multi-stage stratified sampling in China. For each eligible CRC patient with stage III or IV in the selected hospitals, socio-demographics, clinical information, and HRQOL were collected based on patients' self-reporting and/or medical records between March 2020 and March 2021. Patients completed the Functional Assessment of Cancer Therapy Colorectal (FACT-C) plus-traditional Chinese version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-9. Results: A total of 4,589 CRC patients (mean age 60.1 years, including 2,730 males and 1,859 females) were included. The total score of HRQOL in population was 128.2 +/- 24.70. There were significant differences in the overall score of HRQOL in gender, education level, occupation, region, disease type, and disease stage (P<0.05). The score of HRQOL was better in males, undergraduates and above, unemployed/ laid-off, and southwestern and central China. Multivariate analysis showed that education level, occupation, location, number of hospitals visited and treatment methods, and gender were associated with utilities of CRC patients. Conclusions: The HRQOL is an important outcome measure for CRC patients. The HRQOL scores differed according to socio-demographic and clinical characteristics, and findings of these factors were associated with education level, occupation, region, number of visited and treatment methods, and gender.
KeywordHealth-related quality of life (HRQOL) colorectal cancer (CRC) China
Indexed BySCI
Funding ProjectBeijing Love Book Cancer Foundation ; Merck Serono Co. Ltd.
Funding OrganizationBeijing Love Book Cancer Foundation ; Merck Serono Co. Ltd.
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:000785814200081
PublisherAME PUBL CO
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang, Xi; Zhang, Shao-Kai; Qiao, You-Lin
Affiliation1.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Canc Epidemiol,Natl Canc Ctr, Beijing, Peoples R China
2.Baotou Med Coll, Clin Epidmiol Res Ctr, Dept Publ Hlth & Prevent Med, Baotou, Peoples R China
3.Dalian Med Univ, Publ Hlth Sch, Dalian, Peoples R China
4.Jining Med Univ, Sch Nursing, Jining, Peoples R China
5.Univ Elect Sci & Technol China, Sichuan Canc Ctr, Sch Med, Sichuan Canc Hosp & Inst, Chengdu, Peoples R China
6.Zhengzhou Univ, Henan Canc Hosp, Henan Engn Res Ctr Canc Prevent & Control, Dept Canc Epidmiol,Affiliated Canc Hosp,Henan Int, 127 Dongming Rd, Zhengzhou 450008, Peoples R China
7.Guangxi Med Univ, Affiliated Hosp 1, Dept Canc Prevent, Nanning, Peoples R China
8.Guangxi Med Univ, Affiliated Hosp 1, Control Off, Nanning, Peoples R China
9.Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Peoples R China
10.Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Student Affairs, Urumqi, Peoples R China
11.China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Liaoning Off Canc Control & Res, Shenyang, Peoples R China
12.Wuzhou Red Cross Hosp, Dept Gastroenterol, Wuzhou, Peoples R China
13.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Ctr Canc, Guangzhou, Peoples R China
14.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China
15.Xinxiang Cent Hosp, Dept Prevent Hlth, Xinxiang, Henan, Peoples R China
16.Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing, Peoples R China
17.Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China
18.Gansu Prov Canc Hosp, Dept Publ Hlth, Lanzhou, Peoples R China
19.Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China
20.Peking Univ, Canc Hosp & Inst, Beijing Off Canc Prevent & Control, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing, Peoples R China
21.Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Ctr Global Hlth, 9 Dongdansantiao, Beijing 100005, Peoples R China
Recommended Citation
GB/T 7714
Yu, Yan-Qin,Ma, Li,Wang, Wen-Jun,et al. Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey[J]. ANNALS OF TRANSLATIONAL MEDICINE,2022,10.
APA Yu, Yan-Qin.,Ma, Li.,Wang, Wen-Jun.,Zhao, Yu-Qian.,Xu, Hui-Fang.,...&Qiao, You-Lin.(2022).Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey.ANNALS OF TRANSLATIONAL MEDICINE,10.
MLA Yu, Yan-Qin,et al."Health-related quality of life in advanced colorectal cancer patients in China: a nationwide hospital-based survey".ANNALS OF TRANSLATIONAL MEDICINE 10(2022).
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