Knowledge Management System of Hefei Institute of Physical Science,CAS
Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair | |
Zhang, Ben1; Thorne, Rick Francis2; Zhang, Pengfei1,3; Wu, Mian1,2; Liu, Lianxin1,4,5 | |
2022-09-01 | |
发表期刊 | ADVANCED SCIENCE |
通讯作者 | Zhang, Pengfei(zpf1990@ustc.edu.cn) ; Wu, Mian(wumian@ustc.edu.cn) ; Liu, Lianxin(liulx@ustc.edu.cn) |
摘要 | Glucose metabolism contributes to DNA damage response pathways by regulating chromatin remodeling, double-strand break (DSB) repair, and redox homeostasis, although the underlying mechanisms are not fully established. Here, a previously uncharacterized long non-coding RNA is revealed that is call Vanguard which acts to promote HMGB1-dependent DNA repair in association with changes in global chromatin accessibility. Vanguard expression is maintained in cancer cells by SP1-dependent transcription according to glucose availability and cellular adenosine triphosphate (ATP) levels. Vanguard promotes complex formation between HMGB1 and HDAC1, with the resulting deacetylation of HMGB1 serving to maintain its nuclear localization and DSB repair function. However, Vanguard downregulation under glucose limiting conditions promotes HMGB1 translocation from the nucleus, increasing DNA damage, and compromising cancer cell growth and viability. Moreover, Vanguard silencing increases the effectiveness of poly (ADP-ribose) polymerase inhibitors against breast cancer cells with wild-type breast cancer gene-1 status, suggesting Vanguard as a potential therapeutic target. |
关键词 | genomic stability HMGB1 long non-coding RNAs PARP inhibitors Vanguard |
DOI | 10.1002/advs.202201210 |
关键词[WOS] | STRAND BREAK REPAIR ; UP-REGULATION ; CANCER ; HISTONE ; HMGB1 ; EXPRESSION ; METABOLISM ; DYNAMICS ; PROTEIN ; DAMAGE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81820108021] ; National Natural Science Foundation of China[U19A2008] ; National Natural Science Foundation of China[81972307] ; National Natural Science Foundation of China[31871437] ; National Natural Science Foundation of China[32000526] ; National Key R&D Program of China[2019YFA0709300] ; China Postdoctoral Science Foundation[2021T140646] |
项目资助者 | National Natural Science Foundation of China ; National Key R&D Program of China ; China Postdoctoral Science Foundation |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:000848253500001 |
出版者 | WILEY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/131825 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Zhang, Pengfei; Wu, Mian; Liu, Lianxin |
作者单位 | 1.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hepatobiliary Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China 2.Zhengzhou Univ, Henan Int Join Lab Noncoding RNA & Metab Canc, Henan Prov & Zhengzhou City Key Lab Noncoding RNA, Acad Med Sci,Peoples Hosp, Zhengzhou 450053, Henan, Peoples R China 3.Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 4.First Affiliated Hosp USTC, Anhui Prov Key Lab Hepatopancreatobiliary Surg, Hefei 230001, Anhui, Peoples R China 5.First Affiliated Hosp USTC, Anhui Prov Clin Res Ctr Hepatobiliary Dis, Hefei 230001, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,et al. Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair[J]. ADVANCED SCIENCE,2022. |
APA | Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,Wu, Mian,&Liu, Lianxin.(2022).Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair.ADVANCED SCIENCE. |
MLA | Zhang, Ben,et al."Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair".ADVANCED SCIENCE (2022). |
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