Knowledge Management System of Hefei Institute of Physical Science,CAS
Chiral Recognition of D/L-Ribose by Visual and SERS Assessments | |
Yao, Guohua1,2![]() ![]() | |
2023-09-01 | |
发表期刊 | MOLECULES
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通讯作者 | Huang, Qing(huangq@ipp.ac.cn) |
摘要 | Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules. Therefore, the chiral recognition of ribose is of great significance. The traditional method of chiral recognition of ribose is HPLC, which is time-consuming, expensive, and can only be operated in the laboratory. There is no report on optical analytical techniques that can quickly detect the chirality of ribose. In this study, a simple and convenient approach for the chiral recognition of ribose has been developed. beta-cyclodextrin(beta-CD)-coated Ag NPs aggregate after adding D-ribose, so that D-/L-ribose can be identified using visual colorimetry and/or surface-enhanced Raman spectroscopy (SERS). The color change visible to the naked eye can readily distinguish the chirality of ribose, while the SERS method can provide the more sensitive analysis of enantiomeric ribose. The advantages of this method are that it is fast, convenient, low cost, and can be operated outside the laboratory. DFT calculations show that D-ribose and cyclodextrin have the same chirality, forming multiple strong hydrogen bonds between them; thus, D/L-ribose will induce different optical effects. |
关键词 | ribose chiral recognition visual sensor colorimetry SERS |
DOI | 10.3390/molecules28186480 |
关键词[WOS] | DENSITY FUNCTIONALS ; NONCOVALENT INTERACTIONS ; CRYSTAL-STRUCTURE ; ORIGIN ; PERFORMANCE ; ADSORPTION ; M06-2X ; SENSOR ; SUGARS ; DFT |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[21904127] ; National Key R&D Program of China[2022YFA1503504] ; Anhui Provincial Natural Science Foundation[1908085MB53] |
项目资助者 | National Natural Science Foundation of China ; National Key R&D Program of China ; Anhui Provincial Natural Science Foundation |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS记录号 | WOS:001077878700001 |
出版者 | MDPI |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/132505 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Huang, Qing |
作者单位 | 1.Shanghai Normal Univ, Joint Int Res Lab Resource Chem, Educ Minist Key Lab Resource Chem, Minist Educ,Shanghai Noncarbon Energy Convers & Ut, Shanghai 200234, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, CAS Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China |
推荐引用方式 GB/T 7714 | Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,et al. Chiral Recognition of D/L-Ribose by Visual and SERS Assessments[J]. MOLECULES,2023,28. |
APA | Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,&Huang, Qing.(2023).Chiral Recognition of D/L-Ribose by Visual and SERS Assessments.MOLECULES,28. |
MLA | Yao, Guohua,et al."Chiral Recognition of D/L-Ribose by Visual and SERS Assessments".MOLECULES 28(2023). |
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