Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis

doi:10.1177/17588359231197955

HFCAS OpenIR

	Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis
	Wang, Jingwen 5,6,7,8; Zhang, Lijie 5,6,7,8; Wang, Minghe 6,9; Zhang, Jing 5,6,7,8; Wang, Yaqi 5,6,7,8; Wan, Juefeng 5,6,7,8; Li, Guichao 5,6,7,8; Zhang, Hui5,6,7,8 ; Wang, Yan 5,6,7,8; Wu, Ruiyan 5,6,7,8; Zhang, Zhiyuan 5,6,7,8; Li, Xinxiang 6,9; Xu, Ye 6,9; Zhu, Ji 5,6,8,10,11,12; Shen, Lijun 1,2,3,4; Xia, Fan 1,2,3,4; Zhang, Zhen 1,2,3,4
	2023
发表期刊	THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
ISSN	1758-8340
通讯作者	Shen, Lijun(lijunshen@fudan.edu.cn) ; Xia, Fan(tcxiafan@hotmail.com) ; Zhang, Zhen(zhen_zhang@fudan.edu.cn)
摘要	Background: The watch-and-wait (W&W) strategy is a novel treatment option for patients with rectal cancer who have a strong desire for organ preservation. The study aimed to explore the long-term outcomes of the W&W strategy in a large cohort of rectal cancer patients who achieved a clinical complete response (cCR) after consolidation total neoadjuvant therapy (TNT), and to compare with patients who achieved a pathological complete response (pCR) after radical surgery. Methods: The W&W group comprised patients who were assessed as having a cCR after consolidation TNT and adopted the W&W strategy. Patients who underwent standard resection and achieved a pCR were compared as a reference. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier analysis with log-rank test was used to compare survival outcomes. Results: We included 89 and 171 patients in the W&W and pCR groups, respectively. The median follow-up period was 45 and 58 months for the W&W and pCR groups, respectively. After IPTW adjustment, the 2-year local regrowth/recurrence rate for the W&W and pCR groups were 9.9% and 2.0%, respectively (p < 0.001). The W&W and pCR groups had similar 5-year outcomes, including overall survival, disease-free survival, and distant metastasis-free survival (all p > 0.05). No significant difference was observed in the rates of distant metastasis between patients in the W&W group with local regrowth and those without local regrowth (25% versus 6.2%, p = 0.119). Conclusion: Patients who were managed with a W&W strategy after consolidation TNT had favorable survival outcomes, which were similar to those of patients with a pCR. The rate of local regrowth in W&W patients was lower in our study than in other studies as a result of the implementation of consolidation TNT.
关键词	locally advanced rectal cancer neoadjuvant chemoradiotherapy organ preservation total neoadjuvant therapy watch-and-wait
DOI	10.1177/17588359231197955
关键词[WOS]	CLINICAL COMPLETE RESPONDERS ; PREOPERATIVE CHEMORADIOTHERAPY ; ADJUVANT CHEMOTHERAPY ; OPEN-LABEL ; CHEMORADIATION ; MULTICENTER ; RADIOTHERAPY ; SURGERY ; WATCH
收录类别	SCI
语种	英语
资助项目	None.
项目资助者	None.
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:001064840500001
出版者	SAGE PUBLICATIONS LTD
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/132626
专题	中国科学院合肥物质科学研究院
通讯作者	Shen, Lijun; Xia, Fan; Zhang, Zhen
作者单位	1.Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai 200032, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 3.Shanghai Clin Res Ctr Radiat Oncol, Shanghai 200032, Peoples R China 4.Shanghai Key Lab Radiat Oncol, Shanghai 200032, Peoples R China 5.Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China 6.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China 7.Shanghai Clin Res Ctr Radiat Oncol, Shanghai, Peoples R China 8.Shanghai Key Lab Radiat Oncol, Shanghai, Peoples R China 9.Fudan Univ, Shanghai Canc Ctr, Dept Colorectal Surg, Shanghai, Peoples R China 10.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 11.Chinese Acad Sci, Inst Basic Med & Canc, Hangzhou, Peoples R China 12.Zhejing Key Lab Radiat Oncol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jingwen,Zhang, Lijie,Wang, Minghe,et al. Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis[J]. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY,2023,15.
APA	Wang, Jingwen.,Zhang, Lijie.,Wang, Minghe.,Zhang, Jing.,Wang, Yaqi.,...&Zhang, Zhen.(2023).Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis.THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY,15.
MLA	Wang, Jingwen,et al."Long-term outcomes in a retrospective cohort of patients with rectal cancer with complete response after total neoadjuvant therapy: a propensity-score weighted analysis".THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 15(2023).