Knowledge Management System of Hefei Institute of Physical Science,CAS
'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective | |
Fu, Liyi1,2,3; Zhang, Yang2,3; Farokhzad, Ryan A.2,3; Mendes, Barbara B.4; Conde, Joao4; Shi, Jinjun2,3 | |
2023-10-11 | |
发表期刊 | CHEMICAL SOCIETY REVIEWS |
ISSN | 0306-0012 |
通讯作者 | Shi, Jinjun() |
摘要 | Nanotechnology has shown tremendous success in the drug delivery field for more effective and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new class of therapeutics. Various nanoparticle strategies have been developed to improve the systemic delivery of therapeutics, among which surface modification of targeting ligands on nanoparticles has been widely explored for 'active' delivery to a specific organ or diseased tissue. Meanwhile, compelling evidence has recently been reported that organ-selective targeting may also be achievable by systemic administration of nanoparticles without surface ligand modification. In this Review, we highlight this unique set of 'passive' nanoparticles and their compositions and mechanisms for organ-selective delivery. In particular, the lipid-based, polymer-based, and biomimetic nanoparticles with tropism to different specific organs after intravenous administration are summarized. The underlying mechanisms (e.g., protein corona and size effect) of these nanosystems for organ selectivity are also extensively discussed. We further provide perspectives on the opportunities and challenges in this exciting area of organ-selective systemic nanoparticle delivery. This review article highlights a unique set of 'passive' nanoparticles for organ-selective systemic delivery and discusses the underlying biological mechanisms. |
DOI | 10.1039/d2cs00998 |
关键词[WOS] | MESSENGER-RNA DELIVERY ; PROTEIN CORONA ; LIPID NANOPARTICLES ; TARGETED DELIVERY ; DRUG-DELIVERY ; MESOSCALE NANOPARTICLES ; LUNG ENDOTHELIUM ; SIRNA DELIVERY ; LIVER ; ADSORPTION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01CA200900] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL156362] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL158097] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL159012] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL162367] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R33HL168751] ; National Institutes of Health[848325] ; European Research Council - ERC |
项目资助者 | J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th ; National Institutes of Health ; European Research Council - ERC |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:001078874400001 |
出版者 | ROYAL SOC CHEMISTRY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/133436 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Shi, Jinjun |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China 2.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA 3.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA 4.Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, ToxOm,NMS FCM, Lisbon, Portugal |
推荐引用方式 GB/T 7714 | Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,et al. 'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective[J]. CHEMICAL SOCIETY REVIEWS,2023. |
APA | Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,Mendes, Barbara B.,Conde, Joao,&Shi, Jinjun.(2023).'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective.CHEMICAL SOCIETY REVIEWS. |
MLA | Fu, Liyi,et al."'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective".CHEMICAL SOCIETY REVIEWS (2023). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论