Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
| 1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells | |
Zhang, Lei1,2 ; Yang, Xingxing1; Liu, Juanjuan1,2; Luo, Yan1; Li, Zhiyuan1; Ji, Xinmiao1; Wang, Wenchao1; Zhang, Xin1
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| 2015-12-01 | |
| 发表期刊 | SCIENCE BULLETIN
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| 摘要 | Static magnetic field (SMF) has been known to affect cell proliferation in a cell-type-dependent manner, while the mechanism still remains unclear. We found that 1 T moderate intensity SMF inhibits cell proliferation of nasopharyngeal carcinoma CNE-2Z cells and the Akt/ mTOR signaling pathway, which is upregulated in many cancers. mTOR inhibitors are potential chemodrugs, but their clinical effects are limited by the feedback reactivation of other signaling components such as EGFR and Akt. We showed that 1 T SMF increases the antitumor efficacy of mTOR inhibitor Torin 2. In addition, 1 T SMF increases the inhibition efficiency on mTOR substrates phosphorylation and represses the mTOR inhibitor-induced feedback reactivation of EGFR and Akt. Our study not only demonstrates that mTOR/Akt pathway is one of the molecular targets of SMFs in cells, but also reveals the clinical potentials of combinations of mTOR inhibitors and SMFs in cancer treatment. |
| 文章类型 | Article |
| 关键词 | Static Magnetic Field Cell Proliferation Mtor Mtor Inhibitor Feedback Reactivation |
| WOS标题词 | Science & Technology |
| DOI | 10.1007/s11434-015-0950-5 |
| 关键词[WOS] | PI3K/AKT/MTOR PATHWAY ; LUNG-CANCER ; IN-VITRO ; EXPOSURE ; GROWTH ; PROLIFERATION ; AZD8055 ; TARGET ; RICTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; Chinese Academy of Sciences "Hundred Talent Program'' ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000367400300005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/22219 |
| 专题 | 中科院强磁场科学中心 |
| 作者单位 | 1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China |
| 第一作者单位 | 中科院强磁场科学中心 |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Yang, Xingxing,Liu, Juanjuan,et al. 1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells[J]. SCIENCE BULLETIN,2015,60(24):2120-2128. |
| APA | Zhang, Lei.,Yang, Xingxing.,Liu, Juanjuan.,Luo, Yan.,Li, Zhiyuan.,...&Zhang, Xin.(2015).1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells.SCIENCE BULLETIN,60(24),2120-2128. |
| MLA | Zhang, Lei,et al."1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells".SCIENCE BULLETIN 60.24(2015):2120-2128. |
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