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Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts
Wei, Zhengde1; Yang, Nannan1; Liu, Ying2; Yang, Lizhuang1; Wang, Ying1; Han, Long1; Zha, Rujing1; Huang, Ruiqi1; Zhang, Peng3; Zhou, Yifeng1; Zhang, Xiaochu4,5,6
2016-02-16
Source PublicationSCIENTIFIC REPORTS
Volume6Issue:Pages:1-9
AbstractNicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), anterior insula (AI), and thalamus. Although these brain abnormalities are anatomically separated, they may in fact belong to one neural network. However, it is unclear whether circuit-level abnormalities lead to risky decision-making in smokers. In the current study, we used task-based functional magnetic resonance imaging (fMRI) and examined resting-state functional connectivity (RSFC) to study how connectivity between the dACC, insula, and thalamus influence risky decision-making in nicotine addicts. We found that an increase in risky decision-making was associated with stronger nicotine dependence and stronger RSFC of the dACC-rAI (right AI), the dACC-thalamus, the dACC-lAI (left AI), and the rAI-lAI, but that risky decision-making was not associated with risk level-related activation. Furthermore, the severity of nicotine dependence positively correlated with RSFC of the dACC-thalamus but was not associated with risk level-related activation. Importantly, the dACC-thalamus coupling fully mediated the effect of nicotine-dependent severity on risky decision-making. These results suggest that circuit-level connectivity may be a critical neural link between risky decision-making and severity of nicotine dependence in smokers.
SubtypeArticle
WOS HeadingsScience & Technology
Funding OrganizationNational Natural Science Foundation of China(31230032 ; Fundamental Research Funds for the Central Universities of China(WK2070000033) ; Natural Science Fund Project of Anhui Province(1208085MH179) ; 100 Talents Programme of The Chinese Academy of Sciences(KJ2070000018) ; Hefei Science Center, CAS "User with Potential"(2015HSC-UP017) ; 31171083 ; 31471071 ; 31500917) ; National Natural Science Foundation of China(31230032 ; Fundamental Research Funds for the Central Universities of China(WK2070000033) ; Natural Science Fund Project of Anhui Province(1208085MH179) ; 100 Talents Programme of The Chinese Academy of Sciences(KJ2070000018) ; Hefei Science Center, CAS "User with Potential"(2015HSC-UP017) ; 31171083 ; 31471071 ; 31500917)
DOI10.1038/srep21778
WOS KeywordDORSOLATERAL PREFRONTAL CORTEX ; SMOKING CUES ; TASK BART ; MEDIATION ANALYSIS ; BRAIN NETWORKS ; SMOKERS ; INSULA ; FMRI ; DEPENDENCE ; FLUCTUATIONS
Indexed BySCI ; SSCi
Language英语
Funding OrganizationNational Natural Science Foundation of China(31230032 ; Fundamental Research Funds for the Central Universities of China(WK2070000033) ; Natural Science Fund Project of Anhui Province(1208085MH179) ; 100 Talents Programme of The Chinese Academy of Sciences(KJ2070000018) ; Hefei Science Center, CAS "User with Potential"(2015HSC-UP017) ; 31171083 ; 31471071 ; 31500917) ; National Natural Science Foundation of China(31230032 ; Fundamental Research Funds for the Central Universities of China(WK2070000033) ; Natural Science Fund Project of Anhui Province(1208085MH179) ; 100 Talents Programme of The Chinese Academy of Sciences(KJ2070000018) ; Hefei Science Center, CAS "User with Potential"(2015HSC-UP017) ; 31171083 ; 31471071 ; 31500917)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000370233600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/22289
Collection医学物理与技术中心
Affiliation1.Univ Sci & Technol China, Key Lab Brain Funct & Dis, Chinese Acad Sci, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
2.Anhui Med Univ, Prov Hosp, Hefei 230001, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
4.Univ Sci & Technol China, Sch Humanities & Social Sci, Hefei 230026, Anhui, Peoples R China
5.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
6.Univ Sci & Technol China, Ctr Biomed Engn, Hefei 230027, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wei, Zhengde,Yang, Nannan,Liu, Ying,et al. Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts[J]. SCIENTIFIC REPORTS,2016,6(无):1-9.
APA Wei, Zhengde.,Yang, Nannan.,Liu, Ying.,Yang, Lizhuang.,Wang, Ying.,...&Zhang, Xiaochu.(2016).Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts.SCIENTIFIC REPORTS,6(无),1-9.
MLA Wei, Zhengde,et al."Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts".SCIENTIFIC REPORTS 6.无(2016):1-9.
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