Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation

doi:10.1002/psc.2868

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	Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation
	Lan, Huan 1,2; Wu, Kun 3,4; Zheng, Yong 5; Pan, Man 2; Huang, Yi-Chao 1; Gao, Shuai 1,2; Zheng, Qing-Yun 1; Zheng, Ji-Shen 5; Li, Yi-Ming 6,7; Xiao, Bailong 3,4; Liu, Lei1,2
	2016-05-01
发表期刊	JOURNAL OF PEPTIDE SCIENCE
摘要	Mambalgins are a class of 57-residue polypeptide toxins isolated from the venom of the African mamba. They exhibit potent analgesic effects by inhibiting the acid-sensing ion channels. Classified asmembers of the family of three-finger toxins, mambalgins contain four pairs of disulfide bridges that help to stabilize the three-finger scaffold. Here, we report the chemical synthesis of functional mambalgin-1/2/3 by using one-step two-segment hydrazide-based native chemical ligation. The two-segment ligation approach reported here may enable efficient production of mambalgin toxins. These synthetic mambalgins are useful compounds for development of diagnostic or therapeutic reagents. Copyright (C) 2016 European Peptide Society and John Wiley & Sons, Ltd.
文章类型	Article
关键词	Mambalgins Toxin Native Chemical Ligation Peptide Hydrazides Acid-sensing Ion Channels
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1002/psc.2868
关键词[WOS]	SENSING ION CHANNELS ; PAIN-RELIEVING PEPTIDE ; SOLID-PHASE SYNTHESIS ; THERAPEUTIC TARGETS ; MAMBA VENOM ; PROTEINS ; DISEASES ; ASICS ; 1A
收录类别	SCI
语种	英语
项目资助者	National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; National Science Foundation China(21532004 ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Ministry of Science and Technology of China(2013CB932800) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Specialized Research Fund for the Doctoral Program of Higher Education(20120002130004) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; Anhui Provincial Natural Science Foundation(1508085QB30) ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; State Key Laboratory of Medicinal Chemical Biology ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21225207 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21402206 ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043) ; 21572043)
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Analytical
WOS记录号	WOS:000378350700010
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/22460
专题	中科院强磁场科学中心
作者单位	1.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 2.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China 3.Tsinghua Univ, Sch Pharmaceut Sci, IDG McGovern Inst Brain Res, Beijing 100084, Peoples R China 4.Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China 5.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 6.Hefei Univ Technol, Sch Med Engn, Hefei 230009, Peoples R China 7.Nankai Univ, State Key Lab Med Chem Biol, Nankai, Peoples R China
推荐引用方式 GB/T 7714	Lan, Huan,Wu, Kun,Zheng, Yong,et al. Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation[J]. JOURNAL OF PEPTIDE SCIENCE,2016,22(5):320-326.
APA	Lan, Huan.,Wu, Kun.,Zheng, Yong.,Pan, Man.,Huang, Yi-Chao.,...&Liu, Lei.(2016).Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation.JOURNAL OF PEPTIDE SCIENCE,22(5),320-326.
MLA	Lan, Huan,et al."Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation".JOURNAL OF PEPTIDE SCIENCE 22.5(2016):320-326.

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