Aberrant expression of receptor tyrosine kinase EphA7 in breast cancers

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	Aberrant expression of receptor tyrosine kinase EphA7 in breast cancers
	Liu, Zhi 1; Zhang, Qing 1; Li, Xuemin 2; Tao, Zijian 1
	2016
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
摘要	Receptors tyrosine kinase of Eph family play important roles in the vascular development, tissue-border formation, cell migration, axon guidance and angiogenesis. They are reported overexpressed in certain human cancers. The over-expression of Eph receptors in cancers is associated with malignant transformation, tumor metastasis, tumor progression and prognosis. Among the Eph family genes, relatively less attention has been directed toward EphA7 in human tumors. Down-regulation of EphA7 by hypermethylation was found in colorectal cancer, germinal center B-cell lymphoma, gastric cancer, and prostate cancer. The potential role of EphA7 in carcinogenesis of human breast carcinoma has not been addressed. In the present study, we tested the expression of EphA7 protein in normal breast cell line MCF-10A, breast cancer cell lines MCF-7, MDA-MB-231, SK-BR-3 and in a set of 150 invasive ductal cancer specimens by using immunohistochemical staining with an EphA7 specific polyclonal antibody. The relationship between EphA7 protein expression and clinicopathological parameters was analyzed. Loss of EphA7 expression was found in breast cancer cell lines and invasive ductal cancer specimens. The expression of EphA7 was associated with grade (P = 0.014), TNM stage (P = 0.029), lymph node metastasis (P = 0.018) and HER2 status (P = 0.005). Our data indicate that the EphA7 protein lost in most breast cancer samples. The function of EphA7 protein in carcinogenesis of breast cancer may be diverse.
文章类型	Article
关键词	Epha7 Receptor Tyrosine Kinase Breast Cancer
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DIAGNOSIS ; PROGNOSIS ; EPHRIN ; BIOMARKERS ; CARCINOMA ; THERAPY
收录类别	SCI
语种	英语
项目资助者	Science and Technology Project of Anhui Province of China(1501041160) ; Science and Technology Project of Anhui Province of China(1501041160) ; Science and Technology Project of Anhui Province of China(1501041160) ; Science and Technology Project of Anhui Province of China(1501041160)
WOS研究方向	Oncology ; Pathology
WOS类目	Oncology ; Pathology
WOS记录号	WOS:000381729200081
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/23865
专题	中科院强磁场科学中心
作者单位	1.Municipal Peoples Hosp, Dept Pathol, Maanshan 243000, Anhui, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhi,Zhang, Qing,Li, Xuemin,et al. Aberrant expression of receptor tyrosine kinase EphA7 in breast cancers[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2016,9(7):7352-7358.
APA	Liu, Zhi,Zhang, Qing,Li, Xuemin,&Tao, Zijian.(2016).Aberrant expression of receptor tyrosine kinase EphA7 in breast cancers.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,9(7),7352-7358.
MLA	Liu, Zhi,et al."Aberrant expression of receptor tyrosine kinase EphA7 in breast cancers".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 9.7(2016):7352-7358.

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