Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans

doi:10.1038/srep36465

	Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans
	Luo, Xun 1,2,3; Xu, Shengmin 1,4; Yang, Yaning 1,2; Li, Luzhi 1,4; Chen, Shaopeng1,4 ; Xu, An1,4 ; Wu, Lijun1,2,4
	2016-11-04
发表期刊	SCIENTIFIC REPORTS
摘要	Previous studies have indicated that engineered nanomaterials can be transferred through the food chain. However, their potential ecotoxicity to the environment is not fully understood. Here, we systematically evaluated the physiological behavior and toxicity of polyvinylpyrrolidone (PVP)-coated silver nanoparticles (AgNPs) using a food chain model from Escherichia coli (E. coli) to Caenorhabditis elegans (C. elegans). Our results demonstrated that AgNPs accumulated in E. coli could be transferred to the C. elegans, and AgNPs were clearly distributed in the gut lumen, subcutaneous tissue and gonad. After being transferred to C. elegans through the food chain, the accumulated AgNPs caused serious toxicity to the higher trophic level (C. elegans), including effects on germ cell death, reproductive integrity and life span. Relative to larger particles (75 nm), small AgNPs (25 nm) more easily accumulated in the food chain and exhibited a stronger toxicity to the higher trophic level. More importantly, both the AgNPs that had accumulated in C. elegans through the food chain and the resulting impairment of germ cells could be transferred to the next generation, indicating that AgNP can cause genetic damage across generations. Our findings highlight that nanomaterials pose potential ecotoxicity to ecosystems via transport through the food chain.
文章类型	Article
WOS标题词	Science & Technology
DOI	10.1038/srep36465
关键词[WOS]	DNA-DAMAGE RESPONSE ; FOOD-CHAIN ; ENGINEERED NANOPARTICLES ; DAPHNIA-MAGNA ; QUANTUM DOTS ; TOXICITY ; SIZE ; CELL ; NANOSILVER ; IMPACT
收录类别	SCI
语种	英语
项目资助者	National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000387022700001
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/30159
专题	技术生物与农业工程研究所
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 3.Huainan Normal Univ, Sch Bioengn, Huainan 232038, Peoples R China 4.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
第一作者单位	技术生物与农业工程研究所
推荐引用方式 GB/T 7714	Luo, Xun,Xu, Shengmin,Yang, Yaning,et al. Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans[J]. SCIENTIFIC REPORTS,2016,6(无):1-12.
APA	Luo, Xun.,Xu, Shengmin.,Yang, Yaning.,Li, Luzhi.,Chen, Shaopeng.,...&Wu, Lijun.(2016).Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans.SCIENTIFIC REPORTS,6(无),1-12.
MLA	Luo, Xun,et al."Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans".SCIENTIFIC REPORTS 6.无(2016):1-12.

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