Institutional Repository of Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
| Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy | |
Meng, Juan1; Tang, Xianghu1 ; Zhou, Binbin1; Xie, Qiwen2; Yang, Liangbao1
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| 2017-03-01 | |
| 发表期刊 | TALANTA
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| 摘要 | A novel and rapid method to detect cocaine in human urine has been developed by using self-assembly ordered two dimensional (2D) gold nanoparticles (GNPs) film as surface-enhanced Raman spectroscopy (SERS) substrates. In order to obtain high sensitivity, uniformity, and reproducibility of SERS platform, quasi spherical, uniform GNPs were firstly synthesis using seed growth method, in which the GNPs have been functionalized with CTAB to form orderly close-packed GNPs film as SERS substrate. Importantly, the high-performance GNPs on solid substrates can produce a high yield of sub-10-nm gaps which can generate gigantic signals enhancement for analytes adsorbed GNPs surface. In view of the complex component of human urine, we develop a rapid and efficient pretreatment strategy for separation and purification of cocaine by using hexane extraction in real human urine samples within 3 min. With the advantages of better extraction rates (> 75%) examined by ultraperformance liquid chromatography (UPLC) and the excellent signal-to-noise ratio detected by SERS, our pretreatment procedure can efficiently lower the interference of complex biological components in urine. To reach on-spot analyzer, a handheld Raman spectrometer was used for feasible SERS detection of cocaine in real human urine. The favorable results demonstrated our pretreatment strategy combined with SERS platform will be a great prospective method toward rapid, reliable, and on-spot cocaine detection for public safety. |
| 文章类型 | Article |
| 关键词 | Surface-enhanced Raman Spectroscopy Cocaine Urine Liquid-liquid Microextraction Self-assembly |
| WOS标题词 | Science & Technology ; Physical Sciences |
| DOI | 10.1016/j.talanta.2016.10.101 |
| 关键词[WOS] | CHROMATOGRAPHIC ANALYSIS ; MASS-SPECTROMETRY ; SERS SUBSTRATE ; HUMAN-PLASMA ; IDENTIFICATION ; DRUGS ; PERFORMANCE ; SCATTERING ; BENZOYLECGONINE ; SUPERSTRUCTURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; National Science Foundation of China(21571180 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; China Postdoctoral Science Foundation(2016T90590 ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 21505138) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) ; 2015M571950) |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| WOS记录号 | WOS:000393244400096 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/31681 |
| 专题 | 中科院合肥智能机械研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Peoples R China 2.Anhui Publ Secur Dept, Inst Forens, Hefei 230061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Juan,Tang, Xianghu,Zhou, Binbin,et al. Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy[J]. TALANTA,2017,164:693-699. |
| APA | Meng, Juan,Tang, Xianghu,Zhou, Binbin,Xie, Qiwen,&Yang, Liangbao.(2017).Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy.TALANTA,164,693-699. |
| MLA | Meng, Juan,et al."Designing of ordered two-dimensional gold nanoparticles film for cocaine detection in human urine using surface-enhanced Raman spectroscopy".TALANTA 164(2017):693-699. |
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