Institutional Repository of Chinese Acad Sci, Hefei Inst Phys Sci, Inst Appl Technol，Hefei 230031, Anhui, Peoples R China
| The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction | |
Xie, Dongxue1,2; Liu, Zhonghui3; Wu, Jiandong2; Feng, Wenfang1; Yang, Ke2,4 ; Deng, Jixian5; Tian, Ganghong5; Santos, Susy6; Cui, Xueling1,2; Lin, Francis2
| |
| 2017-08-01 | |
| 发表期刊 | EXPERIMENTAL CELL RESEARCH
 |
| 摘要 | Activin A belongs to the superfamily of transforming growth factor beta (TGF beta) and is a critical regulatory cytokine in breast cancer and inflammation. However, the role of activin A in migration of breast cancer cells and immune cells was not well characterized. Here, a microfluidic device was used to examine the effect of activin A on the migration of human breast cancer cell line MDA-MB-231 cells and human blood neutrophils as well as their migratory interaction. We found that activin A promoted the basal migration but impaired epidermal growth factor (EGF)-induced migration of breast cancer cells. By contrast, activin A reduced neutrophil chemotaxis and transendothelial migration to N-Formyl-Met-Leu-Phe (fMLP). Finally, activin A promoted neutrophil chemotaxis to the supernatant from breast cancer cell culture. Collectively, our study revealed the different roles of activin A in regulating the migration of breast cancer cells and neutrophils and their migratory interaction. These findings suggested the potential of activin A as a therapeutic target for inflammation and breast cancers. |
| 文章类型 | Article |
| 关键词 | Activin a Breast Cancer Cells Neutrophils Migration Microfluidic Device |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1016/j.yexcr.2017.05.003 |
| 关键词[WOS] | TRANSENDOTHELIAL MIGRATION ; CHEMOTAXIS ; INVASION ; MICROFLUIDICS ; INFLAMMATION ; FOLLISTATIN ; PROGRESSION ; PHENOTYPE ; ROLES ; FLUID |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; University of Manitoba ; University of Manitoba ; University of Manitoba ; University of Manitoba |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| WOS记录号 | WOS:000404320700013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/31976 |
| 专题 | 应用技术研究所 |
| 作者单位 | 1.Jilin Univ, Coll Basic Med Sci, Dept Genet, Changchun 130021, Peoples R China 2.Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada 3.Jilin Univ, Coll Basic Med Sci, Dept Immunol, Changchun 130021, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Appl Technol, Hefei, Anhui, Peoples R China 5.CNR, Winnipeg, MB R3B 1Y6, Canada 6.Victoria Gen Hosp & River Hts Ft Garry Community, Winnipeg, MB, Canada |
| 推荐引用方式 GB/T 7714 | Xie, Dongxue,Liu, Zhonghui,Wu, Jiandong,et al. The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction[J]. EXPERIMENTAL CELL RESEARCH,2017,357(1):107-115. |
| APA | Xie, Dongxue.,Liu, Zhonghui.,Wu, Jiandong.,Feng, Wenfang.,Yang, Ke.,...&Lin, Francis.(2017).The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction.EXPERIMENTAL CELL RESEARCH,357(1),107-115. |
| MLA | Xie, Dongxue,et al."The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction".EXPERIMENTAL CELL RESEARCH 357.1(2017):107-115. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The effects of activ（1041KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论