EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance

doi:10.1158/0008-5472.CAN-16-0842

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	EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
	Zheng, Xiaohu 1,2,3,4; Fan, Xiaolei 1,2,3,4; Fu, Binqing 1,2,3,4; Zheng, Meijuan 5; Zhang, Aimei 6; Zhong, Kai7 ; Yan, Jialai 8; Sun, Rui 1,2,3,4; Tian, Zhigang 1,2,3,4; Wei, Haiming 1,2,3,4
	2017-01-15
发表期刊	CANCER RESEARCH
摘要	The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia. In this study, we compared gene expression patterns of acute myeloid leukemia (AML) and normal bone marrow samples and found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, with EpCAM(+) leukemic cells exhibiting enhanced chemoresistance and oncogenesis. The chemotherapeutic resistance of EpCAM-positive leukemic cells is a consequence of increased WNT5B signaling. Furthermore, we generated EpCAM antibodies that enabled phagocytosis or cytotoxicity of AML cells by macrophage or natural killer cells, respectively. Finally, EpCAM antibody treatment depleted AML in subcutaneous, disseminated, and intramedullary engrafted mice. In summary, EpCAM exhibits promise as a novel target for the treatment of leukemia. (C) 2016 AACR.
文章类型	Article
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1158/0008-5472.CAN-16-0842
关键词[WOS]	ACUTE MYELOID-LEUKEMIA ; CANCER STEM-CELLS ; TRIFUNCTIONAL ANTIBODY CATUMAXOMAB ; HEPATOCELLULAR-CARCINOMA ; MALIGNANT ASCITES ; NK CELLS ; MONOCLONAL-ANTIBODIES ; PHASE II/III ; LUNG-CANCER ; X ANTI-CD3
收录类别	SCI
语种	英语
项目资助者	Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587)
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000393190600026
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/32819
专题	中科院强磁场科学中心
作者单位	1.Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, Sch Life Sci, Hefei, Peoples R China 3.Univ Sci & Technol China, Med Ctr, Hefei, Peoples R China 4.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China 6.Anhui Prov Hosp, Hefei, Peoples R China 7.Chinese Acad Sci, High Field Magnet Lab, Hefei, Peoples R China 8.Anhui Med Coll, Dept Med Technol, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Xiaohu,Fan, Xiaolei,Fu, Binqing,et al. EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance[J]. CANCER RESEARCH,2017,77(2):482-493.
APA	Zheng, Xiaohu.,Fan, Xiaolei.,Fu, Binqing.,Zheng, Meijuan.,Zhang, Aimei.,...&Wei, Haiming.(2017).EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance.CANCER RESEARCH,77(2),482-493.
MLA	Zheng, Xiaohu,et al."EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance".CANCER RESEARCH 77.2(2017):482-493.

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