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Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage
Ma, Jie1,2; Zhang, Hao2; Cheng, Cheng3; Shen, Jie3; Bao, Lingzhi1; Han, Wei1,4,5
2017-07-01
Source PublicationPLASMA PROCESSES AND POLYMERS
Volume14Issue:7
AbstractNon-thermal plasma (NTP) can induce cancer cell death which is supposed to be mediated by oxidative stress. In this work, the contribution of hydrogen peroxide (H2O2) in NTP induced lung cancer cell damage is quantitatively studied. Our results also show signification production of H2O2 in plasma activated medium (PAM). NTP treatment induce critical raising of cell death, apoptosis, and DNA double-strand breaks (DSBs) in A549 cell. NTP treatment also cause mitochondrial dysfunction and intracellular ROS production in A549 cells. Furthermore, catalase efficiently protect cells from NTP induced A549 cell damage. This work clarified the contribution of H2O2 to plasma induced cancer cell damage.
SubtypeArticle
KeywordApoptosis Catalase Dna Damage Hydrogen Peroxide Non-thermal Plasma
WOS HeadingsScience & Technology ; Physical Sciences
Funding OrganizationChinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Natural Science Fund of Anhui Province(1408085MH180) ; Natural Science Fund of Anhui Province(1408085MH180) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Natural Science Fund of Anhui Province(1408085MH180) ; Natural Science Fund of Anhui Province(1408085MH180) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
DOI10.1002/ppap.201600162
WOS KeywordBARRIER DISCHARGE PLASMA ; OXIDATIVE STRESS ; MELANOMA-CELLS ; COLD-PLASMA ; APOPTOSIS ; INDUCTION ; PATHWAY ; DEATH ; THERAPY ; ARREST
Indexed BySCI
Language英语
Funding OrganizationChinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Natural Science Fund of Anhui Province(1408085MH180) ; Natural Science Fund of Anhui Province(1408085MH180) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Chinese Academy of Sciences (CASHIPS) Dean(YZJJ201331) ; Natural Science Fund of Anhui Province(1408085MH180) ; Natural Science Fund of Anhui Province(1408085MH180) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
WOS Research AreaPhysics ; Polymer Science
WOS SubjectPhysics, Applied ; Physics, Fluids & Plasmas ; Physics, Condensed Matter ; Polymer Science
WOS IDWOS:000405739600008
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33524
Collection医学物理与技术中心
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230031, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Plasma Phys, Hefei 230031, Anhui, Peoples R China
4.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215000, Jiangsu, Peoples R China
5.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215000, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Ma, Jie,Zhang, Hao,Cheng, Cheng,et al. Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage[J]. PLASMA PROCESSES AND POLYMERS,2017,14(7).
APA Ma, Jie,Zhang, Hao,Cheng, Cheng,Shen, Jie,Bao, Lingzhi,&Han, Wei.(2017).Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage.PLASMA PROCESSES AND POLYMERS,14(7).
MLA Ma, Jie,et al."Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage".PLASMA PROCESSES AND POLYMERS 14.7(2017).
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