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Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T
He, Genxia1,2; Qian, Junchao3
2017-09-01
Source PublicationMICROSCOPY RESEARCH AND TECHNIQUE
Volume80Issue:9Pages:1009-1017
AbstractIt was known that Spinal cord injury (SCI) leads to neuronal cell death, axonal damage and demyelination, and often results in severe functional loss. Noninvasive imaging of axonal integrity may hold great importance in clinic. This study evaluated the role of phase imaging in detection of axonal integrity of cranial corticospinal tract after spinal cord injury. Quantitative MR phase imaging and diffusion tensor imaging were performed on a group of rats prior to and after spinal cord injury at 9.4 T in this study. The phase contrast decreased mainly in contralateral white matter containing the corticospinal tract (CST), i.e., pyramid by 46%, two weeks postinjury compared to preinjury levels. Diffusion measurements further showed fractional anisotropy (FA) increased and radial diffusivity (perpendicular to) decreased significantly, and axial diffusivity (vertical bar) remained unchanged in these regions confirmed intact fiber tracts two weeks after injury, precluding the possibility of axonal damage and potential contribution to the shifted susceptibility. It was concluded that phase imaging is a potential endogenous biomarker for brain axonal integrity after spinal cord injury. This novel tool could potentially be applied to diagnose brain pathologies in patients who have spinal cord injury.
SubtypeArticle
KeywordBrain Axonal Integrity Phase Imaging Rats Spinal Cord Injury 9.4 t
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
Funding OrganizationNational Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068)
DOI10.1002/jemt.22895
WOS KeywordWHITE-MATTER CONTRAST ; GRADIENT-ECHO MRI ; HIGH-FIELD MRI ; BIOPHYSICAL MECHANISMS ; MULTIPLE-SCLEROSIS ; FIBER ORIENTATION ; MOTOR CORTEX ; BRAIN-TISSUE ; IRON CONTENT ; REORGANIZATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068)
WOS Research AreaAnatomy & Morphology ; Life Sciences & Biomedicine - Other Topics ; Microscopy
WOS SubjectAnatomy & Morphology ; Biology ; Microscopy
WOS IDWOS:000407928600005
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Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33556
Collection中科院强磁场科学中心
Affiliation1.Anhui 2 Prov Peoples Hosp, Dept Neurol, Hefei, Anhui, Peoples R China
2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
He, Genxia,Qian, Junchao. Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2017,80(9):1009-1017.
APA He, Genxia,&Qian, Junchao.(2017).Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T.MICROSCOPY RESEARCH AND TECHNIQUE,80(9),1009-1017.
MLA He, Genxia,et al."Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T".MICROSCOPY RESEARCH AND TECHNIQUE 80.9(2017):1009-1017.
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