Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T | |
He, Genxia1,2; Qian, Junchao3 | |
2017-09-01 | |
发表期刊 | MICROSCOPY RESEARCH AND TECHNIQUE |
摘要 | It was known that Spinal cord injury (SCI) leads to neuronal cell death, axonal damage and demyelination, and often results in severe functional loss. Noninvasive imaging of axonal integrity may hold great importance in clinic. This study evaluated the role of phase imaging in detection of axonal integrity of cranial corticospinal tract after spinal cord injury. Quantitative MR phase imaging and diffusion tensor imaging were performed on a group of rats prior to and after spinal cord injury at 9.4 T in this study. The phase contrast decreased mainly in contralateral white matter containing the corticospinal tract (CST), i.e., pyramid by 46%, two weeks postinjury compared to preinjury levels. Diffusion measurements further showed fractional anisotropy (FA) increased and radial diffusivity (perpendicular to) decreased significantly, and axial diffusivity (vertical bar) remained unchanged in these regions confirmed intact fiber tracts two weeks after injury, precluding the possibility of axonal damage and potential contribution to the shifted susceptibility. It was concluded that phase imaging is a potential endogenous biomarker for brain axonal integrity after spinal cord injury. This novel tool could potentially be applied to diagnose brain pathologies in patients who have spinal cord injury. |
文章类型 | Article |
关键词 | Brain Axonal Integrity Phase Imaging Rats Spinal Cord Injury 9.4 t |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
DOI | 10.1002/jemt.22895 |
关键词[WOS] | WHITE-MATTER CONTRAST ; GRADIENT-ECHO MRI ; HIGH-FIELD MRI ; BIOPHYSICAL MECHANISMS ; MULTIPLE-SCLEROSIS ; FIBER ORIENTATION ; MOTOR CORTEX ; BRAIN-TISSUE ; IRON CONTENT ; REORGANIZATION |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) |
WOS研究方向 | Anatomy & Morphology ; Life Sciences & Biomedicine - Other Topics ; Microscopy |
WOS类目 | Anatomy & Morphology ; Biology ; Microscopy |
WOS记录号 | WOS:000407928600005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/33556 |
专题 | 中科院强磁场科学中心 |
作者单位 | 1.Anhui 2 Prov Peoples Hosp, Dept Neurol, Hefei, Anhui, Peoples R China 2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | He, Genxia,Qian, Junchao. Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2017,80(9):1009-1017. |
APA | He, Genxia,&Qian, Junchao.(2017).Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T.MICROSCOPY RESEARCH AND TECHNIQUE,80(9),1009-1017. |
MLA | He, Genxia,et al."Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T".MICROSCOPY RESEARCH AND TECHNIQUE 80.9(2017):1009-1017. |
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