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Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways
Liu, Yuan1; Tan, Sheng2,3; Zhang, Hao1; Kong, Xiangjun2,3; Ding, Lili1; Shen, Jie4; Lan, Yan4; Cheng, Cheng4; Zhu, Tao2,3; Xia, Weidong1
2017-08-11
Source PublicationSCIENTIFIC REPORTS
Volume7
AbstractNon-thermal atmospheric plasma (NTP) has shown its selective anticancer effects in many types of tumors in vitro and one of the main mechanisms is that the different increase of intracellular ROS in cancer and homologous normal cells. In this study, we report that NTP treatment reduces the proliferation in triple negative breast cancer (TNBC) and normal cell lines. Simultaneously, STAT3 pathway is inhibited by NTP effects. However, it is observed that normal cells MCF10A are more sensitive to ROS toxicity induced by NTP than cancer cells MDA-MB-231. When 5 mM of ROS inhibitor N-acetyl cysteine (NAC) is employed in NTP treatments, the proliferation of normal breast cells MCF10A recovers. Meanwhile, NTP effects remain significant inhibition of MDA-MB-231 cells. Our results further reveal that NTP can induce apoptosis in MDA-MB-231 cells through inhibiting interleukin-6 receptor (IL-6R) pathway. Moreover, the mechanism of NTP anti-cancer selectivity relates to constantly HER2/Akt activation induced by NTP especially in MCF10A cells but not in MDA-MB-231 cells. Therefore, these two different cell signaling pathways induced by NTP treatments in TNBC and homologous normal cells make NTP becoming a potential tool in future therapy.
SubtypeArticle
WOS HeadingsScience & Technology
Funding OrganizationNational Natural Science Foundation of China(11475174 ; National Natural Science Foundation of China(11475174 ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Natural Science Foundation of Anhui Province(1708085MA13) ; Natural Science Foundation of Anhui Province(1708085MA13) ; National Key Scientific Programme of China(2016YFC1302305) ; National Key Scientific Programme of China(2016YFC1302305) ; ministry of Education(20133402120032) ; ministry of Education(20133402120032) ; 11675177 ; 11675177 ; 81472494 ; 81472494 ; 81502282 ; 81502282 ; 8130232) ; 8130232) ; National Natural Science Foundation of China(11475174 ; National Natural Science Foundation of China(11475174 ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Natural Science Foundation of Anhui Province(1708085MA13) ; Natural Science Foundation of Anhui Province(1708085MA13) ; National Key Scientific Programme of China(2016YFC1302305) ; National Key Scientific Programme of China(2016YFC1302305) ; ministry of Education(20133402120032) ; ministry of Education(20133402120032) ; 11675177 ; 11675177 ; 81472494 ; 81472494 ; 81502282 ; 81502282 ; 8130232) ; 8130232)
DOI10.1038/s41598-017-08792-3
WOS KeywordHYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; CANCER-THERAPY ; APOPTOSIS ; DAMAGE ; DNA ; ROS ; EXPRESSION ; CYTOKINES ; IMPACT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(11475174 ; National Natural Science Foundation of China(11475174 ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Natural Science Foundation of Anhui Province(1708085MA13) ; Natural Science Foundation of Anhui Province(1708085MA13) ; National Key Scientific Programme of China(2016YFC1302305) ; National Key Scientific Programme of China(2016YFC1302305) ; ministry of Education(20133402120032) ; ministry of Education(20133402120032) ; 11675177 ; 11675177 ; 81472494 ; 81472494 ; 81502282 ; 81502282 ; 8130232) ; 8130232) ; National Natural Science Foundation of China(11475174 ; National Natural Science Foundation of China(11475174 ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences(DSJJ-14-YY02) ; Natural Science Foundation of Anhui Province(1708085MA13) ; Natural Science Foundation of Anhui Province(1708085MA13) ; National Key Scientific Programme of China(2016YFC1302305) ; National Key Scientific Programme of China(2016YFC1302305) ; ministry of Education(20133402120032) ; ministry of Education(20133402120032) ; 11675177 ; 11675177 ; 81472494 ; 81472494 ; 81502282 ; 81502282 ; 8130232) ; 8130232)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000407443300028
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33571
Collection中科院等离子体物理研究所
Affiliation1.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China
3.Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
4.Chinese Acad Sci, Inst Plasma Phys, POB 1126, Hefei 230031, Anhui, Peoples R China
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GB/T 7714
Liu, Yuan,Tan, Sheng,Zhang, Hao,et al. Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yuan.,Tan, Sheng.,Zhang, Hao.,Kong, Xiangjun.,Ding, Lili.,...&Xia, Weidong.(2017).Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways.SCIENTIFIC REPORTS,7.
MLA Liu, Yuan,et al."Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways".SCIENTIFIC REPORTS 7(2017).
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