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A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy
Sun, Xiao1,2; Du, Ruohong3; Zhang, Li4; Zhang, Guilong1; Zheng, Xiaojia5; Qian, Junchao7; Tian, Xiaohe8; Zhou, Jiewen6; He, Jiacai5; Wang, Yuanyin5; Wu, Yiqun6; Zhong, Kai7; Cai, Dongqing1; Zou, Duohong6; Wu, Zhengyan1
2017-07-01
发表期刊ACS NANO
卷号11期号:7页码:7049-7059
摘要Incorporation of T-1 and T-2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis and chemotherapy of cancer. However, inappropriate incorporation always encountered many issues, such as low contact area of T-1 contrast material with water-proton, inappropriate distance between T-2 contrast material and water molecule, and undesirable disturbance of T-2 contrast material for T-1 imaging. Those issues seriously limited the T-1 or T-2 contrast effect. In this work, we developed a yolk-like Fe3O4@Gd2O3 nanoplatform functionalized by polyethylene glycol and folic acid (FA), which could efficiently exert their tumor targeted T-1-T-2 dual-mode MR imaging and drug delivery role. First, this nanoplatform possessed a high longitudinal relaxation rate (r(1)) (7.91 mM(-1) s(-1)) and a stronger transverse relaxation rate (r(2)) (386.5 mM(-1) s(-1)) than that of original Fe3O4 (268.1 mM(-1) s(-1)). Second, cisplatin could be efficiently loaded into this nanoplatform (112 mg/g) and showed pH-responsive release behavior. Third, this nanoplatform could be effectively internalized by HeLa cells with time and dosage dependence. Fourth, the FA receptor-mediated nanoplatform displayed excellent T-1-T-2 dual mode MR contrast enhancement and anticancer activity both in vitro and in vivo. Fifth, no apparent toxicity for vital organs was observed with systemic delivery of the nanoplatform in vivo. Thus, this nanoplatform could be a potential nanotheranostic for tumor targeted T-1-T-2 dual-mode MR imaging and chemotherapy.
文章类型Article
关键词Yolk-like Fe3o4@gd2o3 Targeted Dual-mode Mr Imaging Drug Delivery System Cisplatin Ph Responsive Cancer Chemotherapy
WOS标题词Science & Technology ; Physical Sciences ; Technology
资助者National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Anhui science and technology plan project(1604a0802082 ; Anhui science and technology plan project(1604a0802082 ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; 81371114 ; 81371114 ; KFJ-SW-STS-143) ; KFJ-SW-STS-143) ; 1401045013) ; 1401045013) ; 31370983 ; 31370983 ; 81371190 ; 81371190 ; 81401518 ; 81401518 ; 31430028) ; 31430028) ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Anhui science and technology plan project(1604a0802082 ; Anhui science and technology plan project(1604a0802082 ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; 81371114 ; 81371114 ; KFJ-SW-STS-143) ; KFJ-SW-STS-143) ; 1401045013) ; 1401045013) ; 31370983 ; 31370983 ; 81371190 ; 81371190 ; 81401518 ; 81401518 ; 31430028) ; 31430028)
DOI10.1021/acsnano.7b02675
关键词[WOS]DRUG-DELIVERY SYSTEM ; MRI CONTRAST AGENTS ; IRON-OXIDE NANOPARTICLES ; BIOIMAGING AGENT ; FACILE SYNTHESIS ; T-1 ; GADOLINIUM ; SURFACE ; ANGIOGRAPHY ; RELAXATION
收录类别SCI
语种英语
资助者National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Anhui science and technology plan project(1604a0802082 ; Anhui science and technology plan project(1604a0802082 ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; 81371114 ; 81371114 ; KFJ-SW-STS-143) ; KFJ-SW-STS-143) ; 1401045013) ; 1401045013) ; 31370983 ; 31370983 ; 81371190 ; 81371190 ; 81401518 ; 81401518 ; 31430028) ; 31430028) ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2015385) ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Science and Technology Service Programs of Chinese Academy of Sciences(KFJ-STS-ZDTP-002 ; Anhui science and technology plan project(1604a0802082 ; Anhui science and technology plan project(1604a0802082 ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Anhui Province Funds for Distinguished Young Scientists(1508085J08) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Key projects of the outstanding young talents in Colleges and Universities(gxyqZD2016058) ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; Young Top-Notch Talent Support Scheme from Anhui Medical University ; 81371114 ; 81371114 ; KFJ-SW-STS-143) ; KFJ-SW-STS-143) ; 1401045013) ; 1401045013) ; 31370983 ; 31370983 ; 81371190 ; 81371190 ; 81401518 ; 81401518 ; 31430028) ; 31430028)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000406649700053
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33584
专题技术生物与农业工程研究所
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Dept Stomatol, Hefei 230022, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China
6.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Key Lab Stomatol, Dent Clin 2,Sch Med, Shanghai 200001, Peoples R China
7.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
8.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China
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GB/T 7714
Sun, Xiao,Du, Ruohong,Zhang, Li,et al. A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy[J]. ACS NANO,2017,11(7):7049-7059.
APA Sun, Xiao.,Du, Ruohong.,Zhang, Li.,Zhang, Guilong.,Zheng, Xiaojia.,...&Wu, Zhengyan.(2017).A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy.ACS NANO,11(7),7049-7059.
MLA Sun, Xiao,et al."A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy".ACS NANO 11.7(2017):7049-7059.
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