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Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans
Li, Qingqing1,2; Shi, Jue1,2; Chen, Lianyun1; Zhan, Furu1; Yuan, Hang1; Wang, Jun1; Xu, An1; Wu, Lijun1,2,3
2017-08-01
Source PublicationONCOTARGET
Volume8Issue:31Pages:51253-51263
AbstractThough the signaling events involved in radiation induced bystander effects (RIBE) have been investigated both in vitro and in vivo, the spatial function of these communications, especially the related signaling pathways, is not fully elucidated. In the current study, significant increases of DNA damage were clearly observed in C. elegans germline upon irradiation to both intra-system of posterior pharynx and intersystem of vulva, in which more severe damage, even to F1 generation worms, was shown for vulva irradiation. Spatial function assay indicated the DDR key components of mrt-2/hus-1/cep-1/ced-4 were indispensable in germ cells for both sites irradiation, while those components in somatic cells were either not (cep-1/ced-4) or partially (mrt-2/hus-1) required to promote apoptosis. Moreover, production of reactive oxygen species (ROS) indicated by the superoxide dismutase expression and the unfolded protein response of the mitochondria was found systemically involved in the initiation of these processes for both two site irradiation. These results will give a better understanding of the RIBE mechanisms in vivo, and invaluable to assess the clinical relevance to radiotherapy.
SubtypeArticle
KeywordC. Elegans Ddr Tissue Specific Rnai Ros Ribe
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 21407002) ; 21407002) ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 21407002) ; 21407002)
DOI10.18632/oncotarget.17229
WOS KeywordCELL-CYCLE ARREST ; IONIZING-RADIATION ; C. ELEGANS ; IN-VIVO ; INTERCELLULAR COMMUNICATION ; MICROBEAM IRRADIATION ; GENOMIC INSTABILITY ; PARTICLE MICROBEAM ; INDUCED APOPTOSIS ; HUMAN FIBROBLASTS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 21407002) ; 21407002) ; National Natural Science Foundation of China(31470829 ; National Natural Science Foundation of China(31470829 ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; International Partnership Program of Chinese Academy of Sciences(116134KYSB20160084) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; 81273004 ; 81273004 ; 21407002) ; 21407002)
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000406717200086
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33606
Collection技术生物与农业工程研究所
Affiliation1.Chinese Acad Sci, Key Lab Ion Beam Bioengn, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
3.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Qingqing,Shi, Jue,Chen, Lianyun,et al. Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans[J]. ONCOTARGET,2017,8(31):51253-51263.
APA Li, Qingqing.,Shi, Jue.,Chen, Lianyun.,Zhan, Furu.,Yuan, Hang.,...&Wu, Lijun.(2017).Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans.ONCOTARGET,8(31),51253-51263.
MLA Li, Qingqing,et al."Spatial function of the oxidative DNA damage response in radiation induced bystander effects in intra- and inter-system of Caenorhabditis elegans".ONCOTARGET 8.31(2017):51253-51263.
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