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Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield
Wang, Shuansuo1; Wu, Kun2,3; Qian, Qian4; Liu, Qian1; Li, Qi1; Pan, Yajun1; Ye, Yafeng1; Liu, Xueying1; Wang, Jing1; Zhang, Jianqing1; Li, Shan1; Wu, Yuejin2; Fu, Xiangdong1,5
2017-09-01
发表期刊CELL RESEARCH
卷号27期号:9页码:1142-1156
摘要Achieving increased grain productivity has long been the overriding focus of cereal breeding programs. The ideotype approach has been used to improve rice yield potential at the International Rice Research Institute and in China. However, the genetic basis of yield-related traits in rice remains unclear. Here, we show that a major quantitative trait locus, qNPT1, acts through the determination of a 'new plant type' (NPT) architecture characterized by fewer tillers, sturdier culms and larger panicles, and it encodes a deubiquitinating enzyme with homology to human OTUB1. Downregulation of OsOTUB1 enhances meristematic activity, resulting in reduced tiller number, increased grain number, enhanced grain weight and a consequent increase in grain yield in rice. Unlike human OTUB1, OsOTUB1 can cleave both K48- and K63-linked polyubiquitin. OsOTUB1 interacts with the E2 ubiquitin-conjugating protein OsUBC13 and the squamosa promoter-binding protein-like transcription factor OsSPL14. OsOTUB1 and OsSPL14 share common target genes, and their physical interaction limits K63-linked ubiquitination (K63Ub) of OsSPL14, which in turn promotes K48Ub-dependent proteasomal degradation of OsSPL14. Conversely, loss-of-function of OsOTUB1 is correlated with the accumulation of high levels of OsSPL14, resulting in the NPT architecture. We also demonstrated that pyramiding of high-yielding npt1 and dep1-1 alleles provides a new strategy for increasing rice yield potential above what is currently achievable.
文章类型Article
关键词New Plant Type Rice Osotub1 Deubiquitination Osspl14 Grain Yield
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302)
DOI10.1038/cr.2017.98
关键词[WOS]NATURAL VARIATION ; GREEN-REVOLUTION ; INCREASES YIELD ; USE EFFICIENCY ; ARABIDOPSIS ; PROTEIN ; UBIQUITINATION ; ARCHITECTURE ; GENE ; INHIBITION
收录类别SCI
语种英语
资助者National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302)
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000408916300009
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33620
专题中科院强磁场科学中心
作者单位1.Chinese Acad Sci, Natl Ctr Plant Gene Res, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230000, Anhui, Peoples R China
4.China Natl Rice Res Inst, Key Lab Rice Biol, Hangzhou 310006, Zhejiang, Peoples R China
5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
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Wang, Shuansuo,Wu, Kun,Qian, Qian,et al. Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield[J]. CELL RESEARCH,2017,27(9):1142-1156.
APA Wang, Shuansuo.,Wu, Kun.,Qian, Qian.,Liu, Qian.,Li, Qi.,...&Fu, Xiangdong.(2017).Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield.CELL RESEARCH,27(9),1142-1156.
MLA Wang, Shuansuo,et al."Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield".CELL RESEARCH 27.9(2017):1142-1156.
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