Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat | |
Hu, Tao1,2,3; Yuan, Xiaoxue1,2,4; Ye, Rongcai1,2; Zhou, Huiqiao1,2; Lin, Jun1,2; Zhang, Chuanhai1; Zhang, Hanlin1,2; Wei, Gang1,2; Dong, Meng1,2; Huang, Yuanyuan1,2; Lim, Wonchung5; Liu, Qingsong6; Lee, Hyuek Jong1,7; Jin, Wanzhu1 | |
2017-09-01 | |
发表期刊 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY |
摘要 | Polycystic ovary syndrome (PCOS) is a complex endocrinopathy that is characterized by anovulation, hyperandrogenism and polycystic ovary. However, there is a lack of effective treatment for PCOS at present because the pathologic cause of PCOS has not been elucidated. Although it has been known that brown adipose tissue transplantation ameliorates PCOS by activating endogenous BAT, BAT transplantation is not applicable in clinic. Therefore, BAT activation with natural compound could be an effective treatment strategy for PCOS patients. Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat. In addition, the expression levels of ovarian steroidogenic enzymes such as P450C17, aromatase, 3 beta-HSD, 17 beta-HSD and STAR were up-regulated in rutin-treated PCOS rat. Furthermore, acyclicity and the serum level of luteinizing hormone were normalized, and a large number of mature ovulated follicle with a reduction of cystic formation were observed in PCOS rat after rutin treatment. Finally, rutin treatment surprisingly improved fertility and birth defect in PCOS rat. Collectively, our results indicate that rutin treatment significantly improves systemic insulin resistance and ovarian malfunction in PCOS, and our findings in this study provide a novel therapeutic option for the treatment of PCOS by activating BAT with rutin. (C) 2017 Elsevier Inc. All rights reserved. |
文章类型 | Article |
关键词 | Polycystic Ovary Syndrome Brown Adipose Tissue Rutin Insulin Resistance Fertility |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1016/j.jnutbio.2017.04.012 |
关键词[WOS] | GROWTH-FACTOR 21 ; INSULIN-RESISTANCE ; POSTMENOPAUSAL WOMEN ; ADULT HUMANS ; OBESE WOMEN ; PREVALENCE ; FGF21 ; THERMOGENESIS ; ADIPONECTIN ; ENDOCRINE |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) |
WOS研究方向 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
WOS类目 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
WOS记录号 | WOS:000411170200002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/33677 |
专题 | 中科院强磁场科学中心 |
作者单位 | 1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Xuzhou Med Univ, Dept Anat, Basic Med Coll, Xuzhou 221004, Jiangsu, Peoples R China 4.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, 8 East Jingshun St, Beijing 100015, Peoples R China 5.Cheongju Univ, Dept Sports Med, Coll Hlth Sci, Cheongju 363764, South Korea 6.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 7.Ctr Vasc Res, Inst Basic Sci, Daejeon 34141, South Korea |
推荐引用方式 GB/T 7714 | Hu, Tao,Yuan, Xiaoxue,Ye, Rongcai,et al. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2017,47:21-28. |
APA | Hu, Tao.,Yuan, Xiaoxue.,Ye, Rongcai.,Zhou, Huiqiao.,Lin, Jun.,...&Jin, Wanzhu.(2017).Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,47,21-28. |
MLA | Hu, Tao,et al."Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 47(2017):21-28. |
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