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Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat
Hu, Tao1,2,3; Yuan, Xiaoxue1,2,4; Ye, Rongcai1,2; Zhou, Huiqiao1,2; Lin, Jun1,2; Zhang, Chuanhai1; Zhang, Hanlin1,2; Wei, Gang1,2; Dong, Meng1,2; Huang, Yuanyuan1,2; Lim, Wonchung5; Liu, Qingsong6; Lee, Hyuek Jong1,7; Jin, Wanzhu1
2017-09-01
Source PublicationJOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume47Pages:21-28
AbstractPolycystic ovary syndrome (PCOS) is a complex endocrinopathy that is characterized by anovulation, hyperandrogenism and polycystic ovary. However, there is a lack of effective treatment for PCOS at present because the pathologic cause of PCOS has not been elucidated. Although it has been known that brown adipose tissue transplantation ameliorates PCOS by activating endogenous BAT, BAT transplantation is not applicable in clinic. Therefore, BAT activation with natural compound could be an effective treatment strategy for PCOS patients. Here, we found that 3 weeks of rutin (a novel compound for BAT activation) treatment increased BAT activation, thereby it improved thermogenesis and systemic insulin sensitivity in dehydroepiandrosterone (DHEA)-induced PCOS rat. In addition, the expression levels of ovarian steroidogenic enzymes such as P450C17, aromatase, 3 beta-HSD, 17 beta-HSD and STAR were up-regulated in rutin-treated PCOS rat. Furthermore, acyclicity and the serum level of luteinizing hormone were normalized, and a large number of mature ovulated follicle with a reduction of cystic formation were observed in PCOS rat after rutin treatment. Finally, rutin treatment surprisingly improved fertility and birth defect in PCOS rat. Collectively, our results indicate that rutin treatment significantly improves systemic insulin resistance and ovarian malfunction in PCOS, and our findings in this study provide a novel therapeutic option for the treatment of PCOS by activating BAT with rutin. (C) 2017 Elsevier Inc. All rights reserved.
SubtypeArticle
KeywordPolycystic Ovary Syndrome Brown Adipose Tissue Rutin Insulin Resistance Fertility
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationChinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951)
DOI10.1016/j.jnutbio.2017.04.012
WOS KeywordGROWTH-FACTOR 21 ; INSULIN-RESISTANCE ; POSTMENOPAUSAL WOMEN ; ADULT HUMANS ; OBESE WOMEN ; PREVALENCE ; FGF21 ; THERMOGENESIS ; ADIPONECTIN ; ENDOCRINE
Indexed BySCI
Language英语
Funding OrganizationChinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951) ; Chinese Academy of Sciences(XDB13030000) ; Chinese Academy of Sciences(XDB13030000) ; National Natural Science Foundation of China(81370951) ; National Natural Science Foundation of China(81370951)
WOS Research AreaBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS SubjectBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS IDWOS:000411170200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33677
Collection中科院强磁场科学中心
Affiliation1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Xuzhou Med Univ, Dept Anat, Basic Med Coll, Xuzhou 221004, Jiangsu, Peoples R China
4.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, 8 East Jingshun St, Beijing 100015, Peoples R China
5.Cheongju Univ, Dept Sports Med, Coll Hlth Sci, Cheongju 363764, South Korea
6.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
7.Ctr Vasc Res, Inst Basic Sci, Daejeon 34141, South Korea
Recommended Citation
GB/T 7714
Hu, Tao,Yuan, Xiaoxue,Ye, Rongcai,et al. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2017,47:21-28.
APA Hu, Tao.,Yuan, Xiaoxue.,Ye, Rongcai.,Zhou, Huiqiao.,Lin, Jun.,...&Jin, Wanzhu.(2017).Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,47,21-28.
MLA Hu, Tao,et al."Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 47(2017):21-28.
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