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EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression
Chen, Xueran1,2; Ma, Huihui; Wang, Zhen1,2; Zhang, Shangrong1,2; Yang, Haoran1; Fang, Zhiyou1,2
2017-09-15
发表期刊CANCER RESEARCH
卷号77期号:18页码:4998-5010
摘要Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. In this study, we identify a novel mechanism through which mutant p53 drives cancer cell survival and malignant growth. We documented overexpression of the zinc finger protein ZDHHC5 in glioma compared with normal brain tissue and that this event tightly correlated with p53 mutations. Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phosphorylation status of the tumor suppressor EZH2. Taken together, our work highlighted ZDHHC5 as a candidate therapeutic target for management of p53- mutated gliomas. (C) 2017 AACR.
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者National Natural Science Foundation of China(31501171 ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433) ; 31571433) ; 1508085SMC214) ; 1508085SMC214) ; National Natural Science Foundation of China(31501171 ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433) ; 31571433) ; 1508085SMC214) ; 1508085SMC214)
DOI10.1158/0008-5472.CAN-17-1139
关键词[WOS]STEM-LIKE CELLS ; PROTEIN PALMITOYLATION ; S-ACYLTRANSFERASES ; MUTANT TP53 ; P53 ; GLIOBLASTOMA ; CANCER ; GAIN ; DIFFERENTIATION ; TUMORIGENICITY
收录类别SCI
语种英语
资助者National Natural Science Foundation of China(31501171 ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433) ; 31571433) ; 1508085SMC214) ; 1508085SMC214) ; National Natural Science Foundation of China(31501171 ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433) ; 31571433) ; 1508085SMC214) ; 1508085SMC214)
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000410945700023
引用统计
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33686
专题医学物理与技术中心
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Canc Hosp, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Hefei, Anhui, Peoples R China
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Chen, Xueran,Ma, Huihui,Wang, Zhen,et al. EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression[J]. CANCER RESEARCH,2017,77(18):4998-5010.
APA Chen, Xueran,Ma, Huihui,Wang, Zhen,Zhang, Shangrong,Yang, Haoran,&Fang, Zhiyou.(2017).EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.CANCER RESEARCH,77(18),4998-5010.
MLA Chen, Xueran,et al."EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression".CANCER RESEARCH 77.18(2017):4998-5010.
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