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Kinases Involved in Both Autophagy and Mitosis
Li, Zhiyuan; Zhang, Xin
2017-09-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume18Issue:9Pages:1-15
AbstractBoth mitosis and autophagy are highly regulated dynamic cellular processes and involve various phosphorylation events catalysed by kinases, which play vital roles in almost all physiological and pathological conditions. Mitosis is a key event during the cell cycle, in which the cell divides into two daughter cells. Autophagy is a process in which the cell digests its own cellular contents. Although autophagy regulation has mainly been studied in asynchronous cells, increasing evidence indicates that autophagy is in fact tightly regulated in mitosis. Here in this review, we will discuss kinases that were originally identified to be involved in only one of either mitosis or autophagy, but were later found to participate in both processes, such as CDKs (cyclin-dependent kinases), Aurora kinases, PLK-1 (polo-like kinase 1), BUB1 (budding uninhibited by benzimidazoles 1), MAPKs (mitogen-activated protein kinases), mTORC1 (mechanistic target of rapamycin complex 1), AMPK (AMP-activated protein kinase), PI3K (phosphoinositide-3 kinase) and protein kinase B (AKT). By focusing on kinases involved in both autophagy and mitosis, we will get a more comprehensive understanding about the reciprocal regulation between the two key cellular events, which will also shed light on their related therapeutic investigations.
SubtypeReview
KeywordKinases Autophagy Mitosis Cyclin-dependent Kinases Aurora Polo-like Kinases
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Funding OrganizationNational Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045)
DOI10.3390/ijms18091884
WOS KeywordCONSERVED CDC2-RELATED KINASE ; SISTER-CHROMATID COHESION ; CELL-CYCLE ARREST ; CANCER-CELLS ; P38 MAPK ; SIGNALING PATHWAYS ; AURORA KINASE ; MEDIATED PHOSPHORYLATION ; MESENCHYMAL TRANSITION ; MITOTIC PROGRESSION
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045)
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000411963800063
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33798
Collection中科院强磁场科学中心
AffiliationChinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhiyuan,Zhang, Xin. Kinases Involved in Both Autophagy and Mitosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9):1-15.
APA Li, Zhiyuan,&Zhang, Xin.(2017).Kinases Involved in Both Autophagy and Mitosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9),1-15.
MLA Li, Zhiyuan,et al."Kinases Involved in Both Autophagy and Mitosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017):1-15.
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