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Kinases Involved in Both Autophagy and Mitosis
Li, Zhiyuan; Zhang, Xin
2017-09-01
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号18期号:9页码:1-15
摘要Both mitosis and autophagy are highly regulated dynamic cellular processes and involve various phosphorylation events catalysed by kinases, which play vital roles in almost all physiological and pathological conditions. Mitosis is a key event during the cell cycle, in which the cell divides into two daughter cells. Autophagy is a process in which the cell digests its own cellular contents. Although autophagy regulation has mainly been studied in asynchronous cells, increasing evidence indicates that autophagy is in fact tightly regulated in mitosis. Here in this review, we will discuss kinases that were originally identified to be involved in only one of either mitosis or autophagy, but were later found to participate in both processes, such as CDKs (cyclin-dependent kinases), Aurora kinases, PLK-1 (polo-like kinase 1), BUB1 (budding uninhibited by benzimidazoles 1), MAPKs (mitogen-activated protein kinases), mTORC1 (mechanistic target of rapamycin complex 1), AMPK (AMP-activated protein kinase), PI3K (phosphoinositide-3 kinase) and protein kinase B (AKT). By focusing on kinases involved in both autophagy and mitosis, we will get a more comprehensive understanding about the reciprocal regulation between the two key cellular events, which will also shed light on their related therapeutic investigations.
文章类型Review
关键词Kinases Autophagy Mitosis Cyclin-dependent Kinases Aurora Polo-like Kinases
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
资助者National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045)
DOI10.3390/ijms18091884
关键词[WOS]CONSERVED CDC2-RELATED KINASE ; SISTER-CHROMATID COHESION ; CELL-CYCLE ARREST ; CANCER-CELLS ; P38 MAPK ; SIGNALING PATHWAYS ; AURORA KINASE ; MEDIATED PHOSPHORYLATION ; MESENCHYMAL TRANSITION ; MITOTIC PROGRESSION
收录类别SCI
语种英语
资助者National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000411963800063
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33798
专题中科院强磁场科学中心
作者单位Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
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Li, Zhiyuan,Zhang, Xin. Kinases Involved in Both Autophagy and Mitosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9):1-15.
APA Li, Zhiyuan,&Zhang, Xin.(2017).Kinases Involved in Both Autophagy and Mitosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9),1-15.
MLA Li, Zhiyuan,et al."Kinases Involved in Both Autophagy and Mitosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017):1-15.
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