HFCAS OpenIR  > 医学物理与技术中心
Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress
Qi, Nan1; Liu, Chen1,2; Yang, Haoran1,3; Shi, Wanrong4; Wang, Shenyi1; Zhou, Yan1; Wei, Cai5; Gu, Fang1; Qin, Yide1
2017-10-20
发表期刊ONCOTARGET
卷号8期号:50页码:88079-88093
摘要PGPIPN is a therapeutic hexapeptide derived from bovine beta-casein. Here we investigated the role and mechanism of this peptide on alcoholic fatty liver disease (AFLD). We took human hepatic cell line LO2 and hepatocellular carcinoma cell line HepG2 to establish the models of steatosis hepatocyte induced by alcohol, taken PGPIPN as pharmacological intervention. And we also established the model of AFLD mice, taken PGPIPN as therapeutic drug and glutathione (GSH) as positive control. We assayed the biochemical materials related to liver injury, lipid metabolism and oxidation, and observed morphology change and fat accumulation of hepatocyte. The gene expressions and/or activities related to liver injury, lipid metabolism and oxidation, such as ACC, PPAR-gamma, CHOP and Caspase-3, were assessed by real time PCR and western blot. Our results showed PGPIPN alleviated hepatic steatosis in both model cells and AFLD model mice. PGPIPN can effectively reduce the lipid accumulation and oxidative stress of hepatocyte in a dose-dependent manner. PGPIPN alleviated alcohol-induced cell steatosis and injuries by regulating the gene expressions and/or activities of ACC, PPAR-gamma, CHOP and Caspase-3. Our results demonstrated PGPIPN had the protective and therapeutic effect on AFLD, which may serve as a potential therapeutic agent for AFLD.
文章类型Article
关键词Spgpipn Alcoholic Fatty Liver Steatosis Gene Expression
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者National Natural Science Foundation of China(81472448 ; Province Natural Science Foundation of Anhui(1508085MH196) ; Provincial Natural Science Research Project of Anhui(KJ2017A182 ; National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201510366035) ; 30872992) ; KJ2016A336) ; National Natural Science Foundation of China(81472448 ; Province Natural Science Foundation of Anhui(1508085MH196) ; Provincial Natural Science Research Project of Anhui(KJ2017A182 ; National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201510366035) ; 30872992) ; KJ2016A336)
DOI10.18632/oncotarget.21404
关键词[WOS]NF-KAPPA-B ; BIOACTIVE PEPTIDES ; INJURY ; MANAGEMENT ; APOPTOSIS ; PROTEINS ; RATS
收录类别SCI
语种英语
资助者National Natural Science Foundation of China(81472448 ; Province Natural Science Foundation of Anhui(1508085MH196) ; Provincial Natural Science Research Project of Anhui(KJ2017A182 ; National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201510366035) ; 30872992) ; KJ2016A336) ; National Natural Science Foundation of China(81472448 ; Province Natural Science Foundation of Anhui(1508085MH196) ; Provincial Natural Science Research Project of Anhui(KJ2017A182 ; National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201510366035) ; 30872992) ; KJ2016A336)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000413341400087
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33833
专题医学物理与技术中心
作者单位1.Anhui Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hefei 230032, Anhui, Peoples R China
2.Guangming Ctr Hosp, Clin Lab, Shenzhen 518107, Guangdong, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Hefei 230031, Anhui, Peoples R China
4.Anhui Med Univ, Dept Internal Med, Affiliated Hosp 4, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Affiliated Hosp 2, Dept Pharm, Hefei 230601, Anhui, Peoples R China
推荐引用方式
GB/T 7714
Qi, Nan,Liu, Chen,Yang, Haoran,et al. Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress[J]. ONCOTARGET,2017,8(50):88079-88093.
APA Qi, Nan.,Liu, Chen.,Yang, Haoran.,Shi, Wanrong.,Wang, Shenyi.,...&Qin, Yide.(2017).Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress.ONCOTARGET,8(50),88079-88093.
MLA Qi, Nan,et al."Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress".ONCOTARGET 8.50(2017):88079-88093.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Therapeutic hexapept(9229KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qi, Nan]的文章
[Liu, Chen]的文章
[Yang, Haoran]的文章
百度学术
百度学术中相似的文章
[Qi, Nan]的文章
[Liu, Chen]的文章
[Yang, Haoran]的文章
必应学术
必应学术中相似的文章
[Qi, Nan]的文章
[Liu, Chen]的文章
[Yang, Haoran]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Therapeutic hexapeptide (PGPIPN) prevents and cures alcoholic fatty liver disease by affecting the expressions of genes related with lipid metabolism and oxidative stress.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。