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Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma
Chen, Xueran1,2; Wang, Zhen1,2; Ma, Huihui3,4; Zhang, Shangrong1,2; Yang, Haoran1,2; Wang, Hongzhi1,2; Fang, Zhiyou1,2
2017-11-07
发表期刊ONCOTARGET
卷号8期号:55页码:93580-93592
摘要Tumor recurrence in gliomas is partly attributed to increased epithelial-mesenchymal transition (EMT) and enhanced tumor cell dissemination in the adjacent brain parenchyma. Thus, exploring effective strategies for against EMT-like changes in glioma invasion and recurrence will be important for glioma treatment. In this study, we investigated the roles of melatonin in hypoxia-induced EMT suppression, and found that melatonin could significantly suppress the release of the cytokine, CCL20, from cancer cells and antagonize glioma cell metastasis and invasion under hypoxic stress in glioma cells. Furthermore, our findings show that melatonin deregulates Smad7 expression to suppress TGF beta/Smad-mediated increase in CCL20 transcript levels and CCL20-induced EMT occurrence, suggesting a potential anti-EMT therapeutic role for melatonin in malignant transformation in gliomas.
文章类型Article
关键词Melatonin Ccl20 Epithelial-mesenchymal Transition (Emt) Glioma
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131) ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131)
DOI10.18632/oncotarget.20525
关键词[WOS]CANCER STEM-CELLS ; PREDICTS POOR-PROGNOSIS ; TUMOR MICROENVIRONMENT ; CHEMOKINE CCL20 ; DOWN-REGULATION ; GASTRIC-CANCER ; RECEPTOR CCR6 ; METASTASIS ; INVASION ; PROGRESSION
收录类别SCI
语种英语
资助者National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131) ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000414608400035
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.hfcas.ac.cn:8080/handle/334002/33836
专题医学物理与技术中心
作者单位1.Chinese Acad Sci, Canc Hosp, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Hefei 230022, Anhui, Peoples R China
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Chen, Xueran,Wang, Zhen,Ma, Huihui,et al. Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma[J]. ONCOTARGET,2017,8(55):93580-93592.
APA Chen, Xueran.,Wang, Zhen.,Ma, Huihui.,Zhang, Shangrong.,Yang, Haoran.,...&Fang, Zhiyou.(2017).Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma.ONCOTARGET,8(55),93580-93592.
MLA Chen, Xueran,et al."Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma".ONCOTARGET 8.55(2017):93580-93592.
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