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Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma
Chen, Xueran1,2; Wang, Zhen1,2; Ma, Huihui3,4; Zhang, Shangrong1,2; Yang, Haoran1,2; Wang, Hongzhi1,2; Fang, Zhiyou1,2
2017-11-07
Source PublicationONCOTARGET
Volume8Issue:55Pages:93580-93592
AbstractTumor recurrence in gliomas is partly attributed to increased epithelial-mesenchymal transition (EMT) and enhanced tumor cell dissemination in the adjacent brain parenchyma. Thus, exploring effective strategies for against EMT-like changes in glioma invasion and recurrence will be important for glioma treatment. In this study, we investigated the roles of melatonin in hypoxia-induced EMT suppression, and found that melatonin could significantly suppress the release of the cytokine, CCL20, from cancer cells and antagonize glioma cell metastasis and invasion under hypoxic stress in glioma cells. Furthermore, our findings show that melatonin deregulates Smad7 expression to suppress TGF beta/Smad-mediated increase in CCL20 transcript levels and CCL20-induced EMT occurrence, suggesting a potential anti-EMT therapeutic role for melatonin in malignant transformation in gliomas.
SubtypeArticle
KeywordMelatonin Ccl20 Epithelial-mesenchymal Transition (Emt) Glioma
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131) ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131)
DOI10.18632/oncotarget.20525
WOS KeywordCANCER STEM-CELLS ; PREDICTS POOR-PROGNOSIS ; TUMOR MICROENVIRONMENT ; CHEMOKINE CCL20 ; DOWN-REGULATION ; GASTRIC-CANCER ; RECEPTOR CCR6 ; METASTASIS ; INVASION ; PROGRESSION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131) ; National Natural Science Foundation of China(31501171 ; Anhui Provincial Natural Science Foundation(1608085MH180 ; 31571433 ; 1508085SMC214) ; 81773131)
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000414608400035
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/33836
Collection医学物理与技术中心
Affiliation1.Chinese Acad Sci, Canc Hosp, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Hefei 230022, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xueran,Wang, Zhen,Ma, Huihui,et al. Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma[J]. ONCOTARGET,2017,8(55):93580-93592.
APA Chen, Xueran.,Wang, Zhen.,Ma, Huihui.,Zhang, Shangrong.,Yang, Haoran.,...&Fang, Zhiyou.(2017).Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma.ONCOTARGET,8(55),93580-93592.
MLA Chen, Xueran,et al."Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/CCL20 in glioma".ONCOTARGET 8.55(2017):93580-93592.
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