Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
| Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia | |
Liu, Xuesong1,2; Wang, Beilei1,2; Chen, Cheng1,2; Jiang, Zongru1,2; Hu, Chen1,2 ; Wu, Hong1; Zhang, Yicong1,2; Liu, Xiaochuan1; Wang, Wenliang1,2; Wang, Junjie1,2; Hu, Zhenquan1; Wang, Aoli1; Huang, Tao3,4; Liu, Qingwang3,4; Wang, Wei1,4; Wang, Li1,2; Wang, Wenchao1,4; Ren, Tao3,4; Li, Lili5; Xia, Ruixiang5; Ge, Jian5; Liu, Qingsong1,2,3,4,6; Liu, Jing1,4
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| 2018-12-05 | |
| 发表期刊 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| ISSN | 0223-5234 |
| 通讯作者 | Ge, Jian(gejian@ahmu.edu.cn) ; Liu, Qingsong(qsliu97@hmfl.ac.cn) ; Liu, Jing(jingliu@hmfl.ac.cn) |
| 摘要 | There is still a great demand in the clinic for the drugs which can overcome a variety of imatinib resistant ABL mutants. Starting from a type I inhibitor axitinib, which has been reported to overcome ABL-T3151 mutant induced resistance, through a structure guided drug design approach and binding mode switch strategy, we have discovered a novel type II ABL inhibitor 24 (CHMFL-ABL-121), which significantly improved the inhibitory activity against ABL wt and a broad spectrum of mutants including the most prevalent imatinib-resistant gatekeeper mutant 13151. 24 exhibited IC50 values of 2 nM and 0.2 nM against purified inactive ABL wt and 13151 kinase protein respectively and inhibited the proliferation of the established CML cell lines with GI(50) at single digit nM. In cellular context, 24 strongly affected BCR-ABL mediated signaling pathways and induced apoptosis as well as arrested cell cycle at G0/G1 phase. In the in vivo study, 50 mg/kg/day dosage of 24 displayed TGI of 52% in the TEL-ABLT315I-BaF3 cell inoculated allograft mouse model without obvious toxicity. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| 关键词 | ABL kinase Kinase inhibitor ABL mutant CML |
| DOI | 10.1016/j.ejmech.2018.10.007 |
| 关键词[WOS] | BCR-ABL ; IMATINIB ; RESISTANCE ; MECHANISMS ; STRATEGIES ; BCR-ABL1 ; TUMORS ; DRUG |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Frontier Science Key Research Program of CAS[QYZDB-SSW-SLH037] ; Natural Science Foundation of the Anhui Higher Education Institutions of China[KJ2018ZD020] ; Natural Science Foundation of Anhui Province[1708085MH224] ; Natural Science Foundation of Anhui Province[1208085QH154] ; Natural Science Foundation of Anhui Province[1808085MH274] ; Natural Science Foundation of Anhui Province[1708085MH208] ; Major Science and Technology Program of Anhui Province[17030801025] ; Major Science and Technology Program of Anhui Province[16030801114] ; National Key Research and Development Program of China[2016YFA0400900] ; National Natural Science Foundation of China[21708044] ; National Natural Science Foundation of China[81703559] ; National Natural Science Foundation of China[U1532154] ; National Natural Science Foundation of China[81473088] ; National Natural Science Foundation of China[81471773] ; National Natural Science Foundation of China[U1432250] ; National Natural Science Foundation of China[81200371] ; National Natural Science Foundation of China[81200371] ; National Natural Science Foundation of China[U1432250] ; National Natural Science Foundation of China[81471773] ; National Natural Science Foundation of China[81473088] ; National Natural Science Foundation of China[U1532154] ; National Natural Science Foundation of China[81703559] ; National Natural Science Foundation of China[21708044] ; National Key Research and Development Program of China[2016YFA0400900] ; Major Science and Technology Program of Anhui Province[16030801114] ; Major Science and Technology Program of Anhui Province[17030801025] ; Natural Science Foundation of Anhui Province[1708085MH208] ; Natural Science Foundation of Anhui Province[1808085MH274] ; Natural Science Foundation of Anhui Province[1208085QH154] ; Natural Science Foundation of Anhui Province[1708085MH224] ; Natural Science Foundation of the Anhui Higher Education Institutions of China[KJ2018ZD020] ; Frontier Science Key Research Program of CAS[QYZDB-SSW-SLH037] |
| 项目资助者 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:000450383500006 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/34322 |
| 专题 | 中科院强磁场科学中心 合肥创新院 |
| 通讯作者 | Ge, Jian; Liu, Qingsong; Liu, Jing |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Technol Innovat, Precis Targeted Therapy Discovery Ctr, Hefei 230088, Anhui, Peoples R China 4.Precis Med Res Lab Anhui Prov, Hefei 230088, Anhui, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Dept Hematol, Hefei 230022, Anhui, Peoples R China 6.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China |
| 第一作者单位 | 中科院强磁场科学中心 |
| 通讯作者单位 | 中科院强磁场科学中心 |
| 推荐引用方式 GB/T 7714 | Liu, Xuesong,Wang, Beilei,Chen, Cheng,et al. Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,160:61-81. |
| APA | Liu, Xuesong.,Wang, Beilei.,Chen, Cheng.,Jiang, Zongru.,Hu, Chen.,...&Liu, Jing.(2018).Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,160,61-81. |
| MLA | Liu, Xuesong,et al."Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 160(2018):61-81. |
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