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A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy
Zhang, Guilong1; Du, Ruohong2; Qian, Junchao3; Zheng, Xiaojia2; Tian, Xiaohe4; Cai, Dongqing1; He, Jiacai2; Wu, Yiqun5; Huang, Wei5; Wang, Yuanyin2; Zhang, Xin6; Zhong, Kai3; Zou, Duohong2,5; Wu, Zhengyan1
2018-01-07
Source PublicationNANOSCALE
ISSN2040-3364
Abstract

Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid-and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC). This nanosystem showed a prominent T1 contrast with an ultrahigh relaxivity of up to 11.6 mM(-1) s(-1) and pH-responsive drug release behavior. HepG2 cells treated with FA-GCGLD-DOX/COLC were efficiently inhibited, and the cell contrast was enhanced. In vivo, the tumor accumulation of FA-GCGLD-DOX/COLC significantly increased, thereby facilitating the systemic delivery of particles and exerting tumor growth inhibition and an enhanced tumor contrast effect. Moreover, compared to free drugs, FA-GCGLD-DOX/COLC effectively decreased the drug resistance of the tumor, thereby improving the cancer chemotherapeutic efficacy. In addition, injecting rats with FA-GCGLD afforded excellent magnetic resonance angiography (MRA) images with high-resolution vascular structures because of the long blood circulation time of FA-GCGLD. Thus, this study provides a powerful tool for diverse applications in the biomedical field, including accurate diagnosis and chemotherapy of tumors and the detection of cardiovascular diseases.

DOI10.1039/c7nr07957e
WOS KeywordDRUG-DELIVERY SYSTEM ; WALLED CARBON NANOTUBES ; MRI CONTRAST AGENTS ; GRAPHENE OXIDE ; CANCER-CELLS ; GADOLINIUM ; NANOPARTICLES ; THERAPY ; THERANOSTICS ; DOXORUBICIN
Indexed BySCI
Language英语
Funding ProjectFoundation of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine[2015-05] ; Key Projects of the Outstanding Young Talents in Colleges and Universities[gxyqZD2016058] ; Anhui Province Funds for Distinguished Young Scientists[1508085J08] ; Science and Technology Project of Anhui Province[1401045013] ; Science and Technology Project of Anhui Province[1604a0802082] ; Chinese Academy of Sciences[2015385] ; Chinese Academy of Sciences[KFJ-SW-STS-143] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-002] ; Chinese Academy of Sciences[KSZD-EW-Z-022-05] ; National Natural Science Foundation of China[81271162] ; National Natural Science Foundation of China[81371114] ; National Natural Science Foundation of China[31370983] ; National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[31370983] ; National Natural Science Foundation of China[81371114] ; National Natural Science Foundation of China[81271162] ; Chinese Academy of Sciences[KSZD-EW-Z-022-05] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-002] ; Chinese Academy of Sciences[KFJ-SW-STS-143] ; Chinese Academy of Sciences[2015385] ; Science and Technology Project of Anhui Province[1604a0802082] ; Science and Technology Project of Anhui Province[1401045013] ; Anhui Province Funds for Distinguished Young Scientists[1508085J08] ; Key Projects of the Outstanding Young Talents in Colleges and Universities[gxyqZD2016058] ; Foundation of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine[2015-05]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000418621000051
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/34925
Collection技术生物与农业工程研究所
Corresponding AuthorZou, Duohong; Wu, Zhengyan
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
2.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
4.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China
5.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Stomatol, Shanghai Key Lab Stomatol, Dept Oral Surg,Natl Clin Res Ctr Stomatol, Shanghai 200001, Peoples R China
6.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Guilong,Du, Ruohong,Qian, Junchao,et al. A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy[J]. NANOSCALE,2018,10(1):488-498.
APA Zhang, Guilong.,Du, Ruohong.,Qian, Junchao.,Zheng, Xiaojia.,Tian, Xiaohe.,...&Wu, Zhengyan.(2018).A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy.NANOSCALE,10(1),488-498.
MLA Zhang, Guilong,et al."A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy".NANOSCALE 10.1(2018):488-498.
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