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EFFECT OF MELATONIN ON NEURONAL DIFFERENTIATION REQUIRES CBP/P300-MEDIATED ACETYLATION OF HISTONE H3 LYSINE 14
Li, Xian1; Chen, Xueran2; Zhou, Wenjuan1; Ji, Shufang1; Li, Xinyue1; Li, Guanchong1; Liu, Guowei1; Wang, Fuwu1; Hao, Aijun1
2017-11-19
Source PublicationNEUROSCIENCE
ISSN0306-4522
Volume364Issue:Pages:45-59
Abstract

The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons is a multistep process, and the transition is finely regulated by transcription factors with basic helix-loop-helix (bHLH) motifs. Melatonin is an endogenous neurohormone with profound neurotrophic and neuroprotective effects both during the embryonic developmental stage and adulthood. The effects of melatonin on the differentiation of NSCs have been reported, and these effects may be responsible for its neuroprotective properties. However, the mechanisms underlying the effects of melatonin are not well understood. It is unclear whether melatonin affects the expression of bHLH factors at the onset of neuronal differentiation, and the molecular mechanisms involved still need to be further explored. Using mouse NSCs, we identified a novel role for melatonin in the epigenetic regulation of bHLH factors during neuronal differentiation. Our data showed that melatonin promoted neuronal differentiation by specifically increasing the acetylation of histone H3 lysine14 (H3K14). Increased H3K14 acetylation altered the chromatin state of the promoters of bHLH factors Neurogenin1 and NeuroD1 and activated their transcription; then, Neurogenin1 and NeuroD1 initiated and sustained the commitment to neuronal fates. As we know, CBP/p300 is an important class of histone acetyltransferases that acetylate histone H3K14, we found that melatonin activated the histone acetyltransferase activity of CREB-binding protein (CBP)/p300 via ERK signaling pathways. For the first time, we systematically showed the molecular mechanism of action of melatonin, which suggested that melatonin functions as a regulator of the acetylation-dependent gene expression network. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Keywordmelatonin neural stem cells neuronal differentiation histone acetylation histone H3 lysine 14 CREB-binding protein/p300
DOI10.1016/j.neuroscience.2017.07.064
WOS KeywordNEURAL STEM-CELLS ; IN-VITRO ; EMBRYONIC-DEVELOPMENT ; NERVOUS-SYSTEM ; MECHANISMS ; PROLIFERATION ; TRANSCRIPTION ; CHROMATIN ; RECEPTOR ; FATE
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81571093] ; National Natural Science Foundation of China[31271289] ; National Natural Science Foundation of China[31440056] ; Ministry of Education of the People's Republic of China[20110131110036] ; Natural Science Foundation of Shandong Province[2012GS F11842]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000413825900004
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/35951
Collection医学物理与技术中心
Corresponding AuthorHao, Aijun
Affiliation1.Shandong Univ, Key Lab, Minist Educ Expt Teratol,Sch Basic Med Sci, Shandong Prov Key Lab Mental Disorders,Dept Human, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Li, Xian,Chen, Xueran,Zhou, Wenjuan,et al. EFFECT OF MELATONIN ON NEURONAL DIFFERENTIATION REQUIRES CBP/P300-MEDIATED ACETYLATION OF HISTONE H3 LYSINE 14[J]. NEUROSCIENCE,2017,364(无):45-59.
APA Li, Xian.,Chen, Xueran.,Zhou, Wenjuan.,Ji, Shufang.,Li, Xinyue.,...&Hao, Aijun.(2017).EFFECT OF MELATONIN ON NEURONAL DIFFERENTIATION REQUIRES CBP/P300-MEDIATED ACETYLATION OF HISTONE H3 LYSINE 14.NEUROSCIENCE,364(无),45-59.
MLA Li, Xian,et al."EFFECT OF MELATONIN ON NEURONAL DIFFERENTIATION REQUIRES CBP/P300-MEDIATED ACETYLATION OF HISTONE H3 LYSINE 14".NEUROSCIENCE 364.无(2017):45-59.
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