Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
| Crystal structure of the WD40 domain of human PRPF19 | |
Zhang, Yuzhe1,2,3; Li, Yue4 ; Liang, Xiao1; Zhu, Zhongliang4; Sun, Hongbin5; He, Hao2; Min, Jinrong1,2; Liao, Shanhui4; Liu, Yanli1,2
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| 2017-11-25 | |
| 发表期刊 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| ISSN | 0006-291X |
| 摘要 | Human Pre-mRNA Processing factor 19 (hPRPF19) is an important component in human spliceosome machinery. hPRPF19 contains a WD40 repeats domain at its C-terminus, which is also conserved in yeast. Here we determined the crystal structure of the C-terminal WD40 repeat domain of hPRPF19 by X-ray crystallography. Our structural analysis revealed some significantly different structure features between the human and yeast Prp19 WD40 repeat domain. However, there are also conserved clusters of residues at the bottom surface of the fourth and the fifth WD40 repeats, which provides the important implication for the conserved Prp19 proteins in both human and yeast. (C) 2017 Elsevier Inc. All rights reserved. |
| 关键词 | Crystal structure Spliceosome Human Pre-mRNA-processing factor 19 (hPRPF19) |
| DOI | 10.1016/j.bbrc.2017.09.145 |
| 关键词[WOS] | X-RAY-DIFFRACTION ; PROTEIN DATA-BANK ; MACROMOLECULAR CRYSTALLOGRAPHY ; STRUCTURE VALIDATION ; COMPLEX ; PRP19 ; SPLICEOSOME ; RECOGNITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Genome Canada through the Ontario Genomics Institute[OGI-055] ; National Natural Science Foundation of China[31500613] ; National Natural Science Foundation of China[31500601] ; Wellcome Trust[092809/Z/10/Z] ; Takeda ; Pfizer ; Ontario Ministry of Economic Development and Innovation ; National Research Foundation ; Lilly Canada ; Janssen ; GlaxoSmithKline ; Canadian Institutes of Health Research ; Canada Foundation for Innovation ; Boehringer Ingelheim ; AbbVie ; AbbVie ; Boehringer Ingelheim ; Canada Foundation for Innovation ; Canadian Institutes of Health Research ; GlaxoSmithKline ; Janssen ; Lilly Canada ; National Research Foundation ; Ontario Ministry of Economic Development and Innovation ; Pfizer ; Takeda ; Wellcome Trust[092809/Z/10/Z] ; National Natural Science Foundation of China[31500601] ; National Natural Science Foundation of China[31500613] ; Genome Canada through the Ontario Genomics Institute[OGI-055] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| WOS记录号 | WOS:000413991300014 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/36033 |
| 专题 | 中科院强磁场科学中心 |
| 通讯作者 | Liao, Shanhui; Liu, Yanli |
| 作者单位 | 1.Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China 2.Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada 3.Dali Univ, Yunnan Prov Key Lab Entomol Biopharmaceut R&D, Dali 671000, Peoples R China 4.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuzhe,Li, Yue,Liang, Xiao,et al. Crystal structure of the WD40 domain of human PRPF19[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,493(3):1250-1253. |
| APA | Zhang, Yuzhe.,Li, Yue.,Liang, Xiao.,Zhu, Zhongliang.,Sun, Hongbin.,...&Liu, Yanli.(2017).Crystal structure of the WD40 domain of human PRPF19.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,493(3),1250-1253. |
| MLA | Zhang, Yuzhe,et al."Crystal structure of the WD40 domain of human PRPF19".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493.3(2017):1250-1253. |
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| Crystal structure of（807KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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