Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy | |
Wang, Dongdong1,2; Zhou, Jiajia3; Shi, Ruohong1,2; Wu, Huihui3; Chen, Ruhui1,2; Duan, Beichen1,2; Xia, Guoliang1,2; Xu, Pengping1,2; Wang, Hui4; Zhou, Shu3; Wang, Chengming1,2; Wang, Haibao5; Guo, Zhen3; Chen, Qianwang1,2,4 | |
2017 | |
发表期刊 | THERANOSTICS |
ISSN | 1838-7640 |
摘要 | Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs. |
关键词 | MOFs photothermal chemotherapy pH-responsive NIR-responsive |
DOI | 10.7150/thno.20363 |
关键词[WOS] | DRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; IRON-OXIDE ; SUPERPARAMAGNETIC NANOPARTICLES ; MAGNETIC-RESONANCE ; OXIDATIVE STRESS ; MOS2 NANOSHEETS ; GOLD NANORODS ; RELEASE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | [31501130] ; [U1232211] ; [2016YFA0101202] ; CAS Hefei Science Center[2016HSC-IU011] ; National Natural Science Foundation of China[21571168] ; CAS/SAFEA ; CAS/SAFEA ; National Natural Science Foundation of China[21571168] ; CAS Hefei Science Center[2016HSC-IU011] ; [2016YFA0101202] ; [U1232211] ; [31501130] |
WOS研究方向 | Research & Experimental Medicine |
WOS类目 | Medicine, Research & Experimental |
WOS记录号 | WOS:000413224300018 |
出版者 | IVYSPRING INT PUBL |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/36122 |
专题 | 中科院强磁场科学中心 |
通讯作者 | Wang, Haibao; Guo, Zhen; Chen, Qianwang |
作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Hefei 230026, Anhui, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Anhui Key Lab Cellular Dynam & Chem Biol, Hefei 230027, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Radiol Dept, Hefei 230022, Anhui, Peoples R China |
通讯作者单位 | 中科院强磁场科学中心 |
推荐引用方式 GB/T 7714 | Wang, Dongdong,Zhou, Jiajia,Shi, Ruohong,et al. Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy[J]. THERANOSTICS,2017,7(18):4605-4617. |
APA | Wang, Dongdong.,Zhou, Jiajia.,Shi, Ruohong.,Wu, Huihui.,Chen, Ruhui.,...&Chen, Qianwang.(2017).Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy.THERANOSTICS,7(18),4605-4617. |
MLA | Wang, Dongdong,et al."Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy".THERANOSTICS 7.18(2017):4605-4617. |
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