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Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy
Wang, Dongdong1,2; Zhou, Jiajia3; Shi, Ruohong1,2; Wu, Huihui3; Chen, Ruhui1,2; Duan, Beichen1,2; Xia, Guoliang1,2; Xu, Pengping1,2; Wang, Hui4; Zhou, Shu3; Wang, Chengming1,2; Wang, Haibao5; Guo, Zhen3; Chen, Qianwang1,2,4
2017
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume7Issue:18Pages:4605-4617
Abstract

Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs.

KeywordMOFs photothermal chemotherapy pH-responsive NIR-responsive
DOI10.7150/thno.20363
WOS KeywordDRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; IRON-OXIDE ; SUPERPARAMAGNETIC NANOPARTICLES ; MAGNETIC-RESONANCE ; OXIDATIVE STRESS ; MOS2 NANOSHEETS ; GOLD NANORODS ; RELEASE
Indexed BySCI
Language英语
Funding ProjectCAS/SAFEA ; National Natural Science Foundation of China[21571168] ; CAS Hefei Science Center[2016HSC-IU011] ; [2016YFA0101202] ; [U1232211] ; [31501130]
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000413224300018
PublisherIVYSPRING INT PUBL
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/36123
Collection中科院强磁场科学中心
Corresponding AuthorWang, Haibao; Guo, Zhen; Chen, Qianwang
Affiliation1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Hefei 230026, Anhui, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Anhui Key Lab Cellular Dynam & Chem Biol, Hefei 230027, Anhui, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
5.Anhui Med Univ, Affiliated Hosp 1, Radiol Dept, Hefei 230022, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dongdong,Zhou, Jiajia,Shi, Ruohong,et al. Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy[J]. THERANOSTICS,2017,7(18):4605-4617.
APA Wang, Dongdong.,Zhou, Jiajia.,Shi, Ruohong.,Wu, Huihui.,Chen, Ruhui.,...&Chen, Qianwang.(2017).Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy.THERANOSTICS,7(18),4605-4617.
MLA Wang, Dongdong,et al."Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy".THERANOSTICS 7.18(2017):4605-4617.
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