Institutional Repository of Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids | |
Liu, Zhengjie1,2; Zhao, Jun1; Zhang, Ruilong3; Han, Guangmei1,2; Zhang, Cheng1; Liu, Bianhua1; Zhang, Zhongping1,3; Han, Ming-Yong1,4; Gao, Xiaohu5 | |
2018-04-01 | |
发表期刊 | ACS NANO |
ISSN | 1936-0851 |
摘要 | Distinguishing tumor cells from normal cells holds the key to precision diagnosis and effective intervention of cancers. The fundamental difficulties, however, are the heterogeneity of tumor cells and the lack of truly specific and ideally universal cancer biomarkers. Here, we report a concept of tumor cell detection, bypassing the specific genotypic and phenotypic features of different tumor cell types and directly going toward the hallmark of cancer, uncontrollable growth. Combining spherical nucleic acids (SNAs) with exquisitely engineered molecular beacons (SNA beacons, dubbed SNAB technology) is capable of identifying tumor cells from normal cells based on the molecular phenotype of telomerase activity, largely bypassing the heterogeneity problem of cancers. Owing to the cell-entry capability of SNAs, the SNAB probe readily achieves tumor cell detection across multiple platforms, ranging from solution-based assay, to single cell imaging and in vivo solid tumor imaging (unlike PCR that is restricted to cell lysates). We envision the SNAB technology will impact cancer diagnosis, therapeutic response assessment, and image-guided surgery. |
关键词 | telomerase spherical nucleic acids cancer molecular beacons surgery navigation imaging detection |
DOI | 10.1021/acsnano.8b00743 |
关键词[WOS] | MODIFIED GOLD NANOPARTICLES ; MESSENGER-RNA DETECTION ; IN-VIVO ; INTRACELLULAR TELOMERASE ; IMMORTAL CELLS ; DIFFERENTIATION ; DISPLACEMENT ; SENESCENCE ; DELIVERY ; BREAST |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Natural Science Foundation of Anhui Province in China[1608085QB32] ; National Natural Science Foundation of China[21705001] ; National Natural Science Foundation of China[21605145] ; National Natural Science Foundation of China[61705239] ; National Natural Science Foundation of China[21335006] ; National Natural Science Foundation of China[21475135] ; National Natural Science Foundation of China[21775001] ; National Basic Research Program of China[2015CB932002] ; National Basic Research Program of China[2015CB932002] ; National Natural Science Foundation of China[21775001] ; National Natural Science Foundation of China[21475135] ; National Natural Science Foundation of China[21335006] ; National Natural Science Foundation of China[61705239] ; National Natural Science Foundation of China[21605145] ; National Natural Science Foundation of China[21705001] ; Natural Science Foundation of Anhui Province in China[1608085QB32] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:000431088200060 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/36196 |
专题 | 中科院合肥智能机械研究所 |
通讯作者 | Zhang, Zhongping; Gao, Xiaohu |
作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 3.Anhui Univ, Sch Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China 4.ASTAR, Inst Mat Res & Engn, 3 Res Link, Singapore 117602, Singapore 5.Univ Washington, Dept Bioengn, Seattle, WA 98195 USA |
推荐引用方式 GB/T 7714 | Liu, Zhengjie,Zhao, Jun,Zhang, Ruilong,et al. Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids[J]. ACS NANO,2018,12(4):3629-3637. |
APA | Liu, Zhengjie.,Zhao, Jun.,Zhang, Ruilong.,Han, Guangmei.,Zhang, Cheng.,...&Gao, Xiaohu.(2018).Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids.ACS NANO,12(4),3629-3637. |
MLA | Liu, Zhengjie,et al."Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids".ACS NANO 12.4(2018):3629-3637. |
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