HFCAS OpenIR  > 中科院合肥智能机械研究所
Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids
Liu, Zhengjie1,2; Zhao, Jun1; Zhang, Ruilong3; Han, Guangmei1,2; Zhang, Cheng1; Liu, Bianhua1; Zhang, Zhongping1,3; Han, Ming-Yong1,4; Gao, Xiaohu5
2018-04-01
Source PublicationACS NANO
ISSN1936-0851
Volume12Issue:4Pages:3629-3637
Corresponding AuthorZhang, Zhongping(zpzhang@iim.ac.cn) ; Gao, Xiaohu(xgao@u.washington.edu)
AbstractDistinguishing tumor cells from normal cells holds the key to precision diagnosis and effective intervention of cancers. The fundamental difficulties, however, are the heterogeneity of tumor cells and the lack of truly specific and ideally universal cancer biomarkers. Here, we report a concept of tumor cell detection, bypassing the specific genotypic and phenotypic features of different tumor cell types and directly going toward the hallmark of cancer, uncontrollable growth. Combining spherical nucleic acids (SNAs) with exquisitely engineered molecular beacons (SNA beacons, dubbed SNAB technology) is capable of identifying tumor cells from normal cells based on the molecular phenotype of telomerase activity, largely bypassing the heterogeneity problem of cancers. Owing to the cell-entry capability of SNAs, the SNAB probe readily achieves tumor cell detection across multiple platforms, ranging from solution-based assay, to single cell imaging and in vivo solid tumor imaging (unlike PCR that is restricted to cell lysates). We envision the SNAB technology will impact cancer diagnosis, therapeutic response assessment, and image-guided surgery.
Keywordtelomerase spherical nucleic acids cancer molecular beacons surgery navigation imaging detection
Funding OrganizationNational Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China
DOI10.1021/acsnano.8b00743
WOS KeywordMODIFIED GOLD NANOPARTICLES ; MESSENGER-RNA DETECTION ; IN-VIVO ; INTRACELLULAR TELOMERASE ; IMMORTAL CELLS ; DIFFERENTIATION ; DISPLACEMENT ; SENESCENCE ; DELIVERY ; BREAST
Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program of China[2015CB932002] ; National Natural Science Foundation of China[21335006] ; National Natural Science Foundation of China[21475135] ; National Natural Science Foundation of China[21775001] ; National Natural Science Foundation of China[61705239] ; National Natural Science Foundation of China[21605145] ; National Natural Science Foundation of China[21705001] ; Natural Science Foundation of Anhui Province in China[1608085QB32]
Funding OrganizationNational Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China ; Natural Science Foundation of Anhui Province in China
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000431088200060
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/36197
Collection中科院合肥智能机械研究所
Corresponding AuthorZhang, Zhongping; Gao, Xiaohu
Affiliation1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
3.Anhui Univ, Sch Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
4.ASTAR, Inst Mat Res & Engn, 3 Res Link, Singapore 117602, Singapore
5.Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
Recommended Citation
GB/T 7714
Liu, Zhengjie,Zhao, Jun,Zhang, Ruilong,et al. Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids[J]. ACS NANO,2018,12(4):3629-3637.
APA Liu, Zhengjie.,Zhao, Jun.,Zhang, Ruilong.,Han, Guangmei.,Zhang, Cheng.,...&Gao, Xiaohu.(2018).Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids.ACS NANO,12(4),3629-3637.
MLA Liu, Zhengjie,et al."Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids".ACS NANO 12.4(2018):3629-3637.
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