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Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report
Liao, Jia-Ming1; Wang, Wei2; Xie, Jing3; Wu, Hai-Bo3
2018-05-01
Source PublicationMEDICINE
ISSN0025-7974
Volume97Issue:20Pages:4
Corresponding AuthorWu, Hai-Bo(bbwuhaibo@sina.com)
AbstractRationale:Pilocytic astrocytoma (PA) typically shows biphasic pattern with a mixture of loose microcystic and compact regions, in which it is not uncommon to see heterogeneous morphology. However, there has not been reported in the literatures of the PA type that shows similarity to dysembryoplastic neuroepithelial tumor (DNT) in both histological morphology and immunophenotype.Patient concerns:The present study described a case of PA affecting the right temporal-occipital lobe in a 22-year-old male patient. Morphologically, it composed of totally distinctive microcystic pattern. The classical biphasic pattern of PA was not observed. Immunohistochemically, neuronal marker NeuN was expressed in tumor cells scattered in the background which simulated its expression morphology in DNT. However, KIAA1549-BRAF fusion gene was identified by fluorescence in situ hybridization (FISH), supporting for the diagnosis of PA.Diagnoses:DNT-like PA (WHO grade I).Interventions:The tumor was totally removed via a right temporal-occipital craniotomy.Outcomes:The patient is free of local recurrence and dissemination eleven months after surgical resection of the lesion.Lessons:We herein report a rare case of DNT-like PA. For diagnosis, KIAA1549-BRAF fusion gene should be detected under similar situation.
Keyworddysembryoplastic neuroepithelial tumor fluorescence in situ hybridisation KIAA1549-BRAF fusion gene pilocytic astrocytoma
DOI10.1097/MD.0000000000010755
WOS KeywordSEPTUM PELLUCIDUM ; BRAF ; HETEROGENEITY ; MUTATION
Indexed BySCI
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000434305900037
PublisherLIPPINCOTT WILLIAMS & WILKINS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/37082
Collection中科院强磁场科学中心
Corresponding AuthorWu, Hai-Bo
Affiliation1.Southern Dist Anhui Prov Hosp, Dept Clin Lab, Hefei, Anhui, Peoples R China
2.Chinese Acad Sci, High Magnet Field Lab, Hefei, Anhui, Peoples R China
3.Southern Dist Anhui Prov Hosp, Dept Pathol, 1 Swan Lake Rd, Hefei 230036, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Liao, Jia-Ming,Wang, Wei,Xie, Jing,et al. Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report[J]. MEDICINE,2018,97(20):4.
APA Liao, Jia-Ming,Wang, Wei,Xie, Jing,&Wu, Hai-Bo.(2018).Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report.MEDICINE,97(20),4.
MLA Liao, Jia-Ming,et al."Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report".MEDICINE 97.20(2018):4.
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