Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus

doi:10.1002/1873-3468.13172

HFCAS OpenIR > 中科院强磁场科学中心

	Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus
	Wang, Yujuan1,2 ; Yang, Jing1,2 ; Wang, Jiarong1,2 ; Zhu, Lei1,2 ; Wang, Junfeng 1,2,3
	2018-08-01
发表期刊	FEBS LETTERS
ISSN	1873-3468
通讯作者	Wang, Yujuan(Yjwang@hmfl.ac.cn) ; Wang, Junfeng(Junfeng@hmfl.ac.cn)
摘要	PBIF2 is a proapoptotic protein encoded by an alternative reading frame in the influenza A virus. Its accumulation accelerates mitochondrial fragmentation by decreasing the mitochondrial membrane potential following translocation into the mitochondrial inner membrane space, but the mechanistic underpinnings remain unclear. Herein, the PB1F2 from HK97 was expressed and purified in soluble form. The interaction between PBIF2 and the mitochondrial membrane were investigated using three membrane mimics, liposomes, bicelles, and nanodiscs. We show that the interactions between PBIF2 and membrane mimics depend on lipid type and are time- and dose-dependent. The primary membrane target of PBIF2 is phosphatidylcholine, the lipid that forms the major component of mitochondria! inner membranes. PBIF2 disrupts the integrity of lipid membranes by forming micelle-like PBIF2-lipid assemblies.
关键词	influenza A virus membrane disruption micelle-like lipid assembly NMR PB1F2
DOI	10.1002/1873-3468.13172
关键词[WOS]	PB1-F2 PROTEIN ; MITOCHONDRIAL-MEMBRANE ; PORE FORMATION ; DAMAGE ; OLIGOMERS ; DOMAIN ; BETA
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31200579] ; National Natural Science Foundation of China[21473210] ; National Natural Science Foundation of China[21502196] ; National Natural Science Foundation of China[U1532269] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX005] ; National Natural Science Foundation of China[31200579] ; National Natural Science Foundation of China[21473210] ; National Natural Science Foundation of China[21502196] ; National Natural Science Foundation of China[U1532269] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX005]
项目资助者	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 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Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000441436400007
出版者	WILEY
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/37694
专题	中科院强磁场科学中心
通讯作者	Wang, Yujuan; Wang, Junfeng
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China
第一作者单位	中科院强磁场科学中心
通讯作者单位	中科院强磁场科学中心
推荐引用方式 GB/T 7714	Wang, Yujuan,Yang, Jing,Wang, Jiarong,et al. Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus[J]. FEBS LETTERS,2018,592(15):2572-2581.
APA	Wang, Yujuan,Yang, Jing,Wang, Jiarong,Zhu, Lei,&Wang, Junfeng.(2018).Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus.FEBS LETTERS,592(15),2572-2581.
MLA	Wang, Yujuan,et al."Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus".FEBS LETTERS 592.15(2018):2572-2581.