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Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy
Wang, Dan1; Lin, Haiyan2; Zhang, Guilong5; Si, Yuanchun1; Yang, Hongyi6; Bai, Guo3,4; Yang, Chi3,4; Zhong, Kai6; Cai, Dongqing5; Wu, Zhengyan5; Wang, Renfei2; Zou, Duohong1,3,4
2018-09-19
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Corresponding AuthorWang, Renfei(hzwrf@163.com) ; Zou, Duohong(zouduohong@126.com)
AbstractCurrent magnetic resonance imaging (MRI)-guided pH-switching therapeutic platforms have encountered problems such as low relaxation rates, poor pH-switching efficiencies, and a lag in the drug release behind the MRI. Herein, we designed a nanoplatform with tunable pore size, which could match the size of drug molecules for pH-switching MRI and chemotherapy via ultrasmall manganese oxide-capped mesoporous silica nanoparticles (USMO@MSNs). USMO@MSN could quickly dissolve under weakly acidic conditions and leach abundant Mn2+ ions (leaching ratio: 76%), enhancing the MR contrast. The longitudinal relaxation rate (r(1)) of USMO@MSNs significantly increased from 0.65 to 5.61 mM(-1) s(-1) as the pH decreased from 7.4 to 4.5, showing an ultrahigh-efficiency pH-switching T-1-weighted MR contrast ability for in vivo tumor. Meanwhile, the matching pore structure allowed effective loading of doxorubicin (DOX) on USMO@MSNs to form smart therapeutic system (USMO@MSNs-DOX). The DOX release rate was strongly proportional to the pH-switching MRI signal of USMO@MSNs-DOX, allowing the release of DOX to be efficiently monitored by MRI. Confocal observations indicated that USMO@MSNs-DOX could be effectively internalized by HSC3 cells, and the entire system showed a good pH-switching theranostic performance for HSC3 cells. Therefore, this simple pH-switching system provides a new avenue for timely cancer diagnosis and personalized therapy.
KeywordpH-activated synchronous MRI theranostic platform tumor chemotherapy
DOI10.1021/acsami.8b11408
WOS KeywordDRUG-DELIVERY SYSTEM ; MRI CONTRAST AGENTS ; MESOPOROUS SILICA ; BIOIMAGING AGENT ; CARRIER SYSTEM ; TUMOR ACIDITY ; T-1 CONTRAST ; NANOPARTICLES ; GADOLINIUM ; DENDRIMER
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21407151] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province[17030701051] ; Natural Science Foundation of Anhui Province[1808085MB38] ; Zhejiang Characteristic Discipline[2014-112-01] ; Zhejiang Provincial Health Science and Technology Project[2017H011] ; National Natural Science Foundation of China[21407151] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province[17030701051] ; Natural Science Foundation of Anhui Province[1808085MB38] ; Zhejiang Characteristic Discipline[2014-112-01] ; Zhejiang Provincial Health Science and Technology Project[2017H011]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Characteristic Discipline ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project ; Zhejiang Provincial Health Science and Technology Project
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000445439900022
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/39002
Collection中科院强磁场科学中心
技术生物与农业工程研究所
Corresponding AuthorWang, Renfei; Zou, Duohong
Affiliation1.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Anhui, Peoples R China
2.Univ Chinese Acad Sci, Hangzhou Stomatol Hosp, Hangzhou 310002, Zhejiang, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Natl Clin Res Ctr Oral Dis, Dept Oral Surg,Peoples Hosp 9,Sch Med, Shanghai 200001, Peoples R China
4.Shanghai Res Inst Stomatol, Shanghai 200001, Peoples R China
5.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
6.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dan,Lin, Haiyan,Zhang, Guilong,et al. Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(37):31114-31123.
APA Wang, Dan.,Lin, Haiyan.,Zhang, Guilong.,Si, Yuanchun.,Yang, Hongyi.,...&Zou, Duohong.(2018).Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,10(37),31114-31123.
MLA Wang, Dan,et al."Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 10.37(2018):31114-31123.
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