Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris

doi:10.1016/j.biortech.2018.07.151

	Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris
	Ma, Yuhan 1; Balamurugan, Srinivasan 2; Yuan, Wasiqi 2; Yang, Fan 3; Tang, Caiguo 1; Hu, Hao 1; Zhang, Huilan 1; Shu, Xian 1; Li, Minghao1 ; Huang, Shengwei1 ; Li, Hongye 2; Wu, Lifang1
	2018-12-01
发表期刊	BIORESOURCE TECHNOLOGY
ISSN	0960-8524
通讯作者	Wu, Lifang(lfwu@ipp.ac.cn)
摘要	Provision of chemical modulators has emerged as an effective strategy to govern cell growth and development. Here, the impact of flavonoid quercetin on algal growth, lipid accumulation and transcriptional patterns was investigated in the green microalga Chlorella vulgaris. These results demonstrated that quercetin (15 mu g/l) significantly enhanced the cellular biomass and photosynthetic efficiency, with up to 2.5-fold in the biomass in the stationary phase. Lipidomic analyses revealed that lipid content was increased by 1.8-fold. Furthermore, the functional mechanism of quercetin on the molecular level was dissected by transcriptomic analysis. Results revealed that quercetin upregulated the expression pattern of key genes involved in cellular signaling mechanisms such as phosphatidylinositol 4-kinase alpha, thus consequently enhanced cell growth. Altogether, the data present in this study demonstrate the dramatic role of quercetin on enhancing microalgal biomass and lipid accumulation by unprecedented regulation, of key metabolic nodes, for the first time and provide a novel insight into microalgal metabolism and regulation.
关键词	Chlorella vulgaris Quercetin Chemical modulator Biomass Lipid
DOI	10.1016/j.biortech.2018.07.151
关键词[WOS]	TRANSGENIC ARABIDOPSIS-THALIANA ; STRESS TOLERANCE ; GENE-EXPRESSION ; ABIOTIC STRESS ; PLANTS ; FLAVONOIDS ; PRODUCTIVITY ; PYRENOIDOSA ; METABOLISM ; PATHWAYS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China, China[31500531] ; Chinese Academy of Sciences, China[KFJ-STS-ZDTP-002] ; key program of 13th five-year plan, CASHIPS, China[kp-2017-21] ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China[YZJJ201619] ; major special project of Anhui Province, China[16030701103] ; Natural Science Foundation of Anhui province, China[1708085QC70] ; Natural Science Foundation of Anhui province, China[1808085QC73] ; National Natural Science Foundation of China, China[31500531] ; Chinese Academy of Sciences, China[KFJ-STS-ZDTP-002] ; key program of 13th five-year plan, CASHIPS, China[kp-2017-21] ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China[YZJJ201619] ; major special project of Anhui Province, China[16030701103] ; Natural Science Foundation of Anhui province, China[1708085QC70] ; Natural Science Foundation of Anhui province, China[1808085QC73]
项目资助者	National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China ; National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; National Natural Science Foundation of China, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; Chinese Academy of Sciences, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; key program of 13th five-year plan, CASHIPS, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; major special project of Anhui Province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China ; Natural Science Foundation of Anhui province, China
WOS研究方向	Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS类目	Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS记录号	WOS:000445897400053
出版者	ELSEVIER SCI LTD
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/39271
专题	技术生物与农业工程研究所
通讯作者	Wu, Lifang
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 2.Jinan Univ, Coll Life Sci, Key Lab Eutrophicat & Red Tide Prevent, Guangdong Higher Educ Inst, Guangzhou 510632, Guangdong, Peoples R China 3.Anhui Agr Univ, Sch Forestry & Landscape Architecture, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Ma, Yuhan,Balamurugan, Srinivasan,Yuan, Wasiqi,et al. Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris[J]. BIORESOURCE TECHNOLOGY,2018,269:434-442.
APA	Ma, Yuhan.,Balamurugan, Srinivasan.,Yuan, Wasiqi.,Yang, Fan.,Tang, Caiguo.,...&Wu, Lifang.(2018).Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris.BIORESOURCE TECHNOLOGY,269,434-442.
MLA	Ma, Yuhan,et al."Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris".BIORESOURCE TECHNOLOGY 269(2018):434-442.