Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis

doi:10.1021/acs.jnatprod.8b00638

HFCAS OpenIR > 中科院强磁场科学中心

	Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis
	Wang, Qi 1,2; Hu, Zhenquan 1; Li, Xixiang1 ; Wang, Aoli1 ; Wu, Hong1 ; Liu, Jing 1; Cao, Shugeng 3; Liu, Qingsong1,4
	2018-11-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
通讯作者	Cao, Shugeng(scao@hawaii.edu) ; Liu, Qingsong(qsliu97@hmfl.ac.cn)
摘要	Six new phenolic acid derivatives, salviachi-nensines A-F (1-6), together with 14 known compounds (7-20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A-F (1-6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis-trans isomers, and compounds 5 and 6 a pair of epimers. The solvent induced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1-6, as well as the antiproliferative property and the ability of 1 to induce apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated.
DOI	10.1021/acs.jnatprod.8b00638
关键词[WOS]	ACID PHENETHYL ESTER ; ATNICOMPLEMENTARY CONSTITUENTS ; CHEMICAL-CONSTITUENTS ; DITERPENOIDS ; ANTIOXIDANT ; TERPENOIDS ; INHIBITORS ; ROOTS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U1432250] ; National Natural Science Foundation of China[U1532154] ; National Natural Science Foundation of China[81773777] ; National Natural Science Foundation of China[81473088] ; National Natural Science Foundation of China[81703559] ; China Postdoctoral Science Foundation[2017M622036] ; China Postdoctoral Science Foundation[2018M630720] ; China Postdoctoral Science Foundation[2018T110634] ; Natural Science Foundation of Anhui Province[1808085MH274] ; Frontier Science Key Research Program of CAS[QYZDB-SW-SLH037] ; National Natural Science Foundation of China[U1432250] ; National Natural Science Foundation of China[U1532154] ; National Natural Science Foundation of China[81773777] ; National Natural Science Foundation of China[81473088] ; National Natural Science Foundation of China[81703559] ; China Postdoctoral Science Foundation[2017M622036] ; China Postdoctoral Science Foundation[2018M630720] ; China Postdoctoral Science Foundation[2018T110634] ; Natural Science Foundation of Anhui Province[1808085MH274] ; Frontier Science Key Research Program of CAS[QYZDB-SW-SLH037]
项目资助者	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS ; Frontier Science Key Research Program of CAS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000451496100024
出版者	AMER CHEMICAL SOC
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/40238
专题	中科院强磁场科学中心
通讯作者	Cao, Shugeng; Liu, Qingsong
作者单位	1.Chinese Acad Sci, High Field Magnet Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 2.Qingdao Univ, Inst Chron Dis, Qingdao 266003, Peoples R China 3.Univ Hawaii, Dept Pharmaceut Sci, Daniel K Inouye Coll Pharm, Hilo, HI 96720 USA 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
第一作者单位	中科院强磁场科学中心
通讯作者单位	中科院强磁场科学中心
推荐引用方式 GB/T 7714	Wang, Qi,Hu, Zhenquan,Li, Xixiang,et al. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(11):2531-2538.
APA	Wang, Qi.,Hu, Zhenquan.,Li, Xixiang.,Wang, Aoli.,Wu, Hong.,...&Liu, Qingsong.(2018).Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis.JOURNAL OF NATURAL PRODUCTS,81(11),2531-2538.
MLA	Wang, Qi,et al."Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis".JOURNAL OF NATURAL PRODUCTS 81.11(2018):2531-2538.