HFCAS OpenIR  > 中科院固体物理研究所
Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer
Zhang, Hao1,2,3; Chen, Yaodong4; Cai, Yunyu1,2; Liu, Jun1,2; Liu, Pengfei5; Li, Zizhuo4; An, Tingting4; Yang, Xiuhua4; Liang, Changhao1,2,3
2019
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume7Issue:1Pages:409-418
Abstract

The development of nanoplatforms with integrated therapeutic and imaging functions is necessary for highly efficient cancer therapy. Herein, 3D CuS hollow nanoflowers (HNs) consisting of 2D nanoplates are successfully fabricated through the technique of laser ablation in liquids followed by ion-exchange reactions and applied for the first time as a theranostic nanoagent for magnetic resonance imaging (MRI), photothermal therapy (PTT), and chemotherapy simultaneously. Due to the sufficient and immediate contact between the exposed cupric centers of nanoplates and protons from water molecules, CuS HNs are demonstrated to be capable of being a T-1 positive contrast agent for efficient MRI of tumors on the T-2-weighted fluid-attenuated inversion recovery imaging (T-2-FLAIR) sequence. Besides, the hollow structure makes CuS HNs an efficient nanoplatform for drug loading with a laser-triggered drug release. Moreover, CuS HNs exhibit high photothermal conversion efficiency (30%) and good biocompatibility. The combination of PTT and chemotherapy with CuS HNs provides a significant synergistic therapeutic effect, resulting in a higher tumor inhibition ratio than PTT or chemotherapy alone. This study demonstrates a single-component multifunctional theranostic nanoagent for T-2-FLAIR MRI guided thermochemotherapy, which has great potential application in theranostics of cancer.

DOI10.1039/c8bm01412d
WOS KeywordPHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; POLYDOPAMINE NANOPARTICLES ; CONVERSION EFFICIENCY ; SYNERGISTIC THERAPY ; CONTRAST AGENTS ; ABLATION ; NANOSPHERES ; NANOCRYSTALS ; PH
Indexed BySCI
Language英语
Funding ProjectInstrument Developing Project of the Chinese Academy of Sciences[YZ201627] ; National Natural Science Foundation of China (NSFC)[11604320] ; National Natural Science Foundation of China (NSFC)[11674321] ; National Natural Science Foundation of China (NSFC)[11504375] ; National Natural Science Foundation of China (NSFC)[51571186] ; National Basic Research Program of China[2014CB931704] ; National Basic Research Program of China[2014CB931704] ; National Natural Science Foundation of China (NSFC)[51571186] ; National Natural Science Foundation of China (NSFC)[11504375] ; National Natural Science Foundation of China (NSFC)[11674321] ; National Natural Science Foundation of China (NSFC)[11604320] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201627]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000454085700028
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/40825
Collection中科院固体物理研究所
Corresponding AuthorCai, Yunyu; Yang, Xiuhua; Liang, Changhao
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Anhui, Peoples R China
3.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei 230026, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 1, Dept Abdominal Ultrasound, Harbin 150001, Heilongjiang, Peoples R China
5.Harbin Med Univ, Affiliated Hosp 1, Dept Magnet Resonance, Harbin 150001, Heilongjiang, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Hao,Chen, Yaodong,Cai, Yunyu,et al. Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer[J]. BIOMATERIALS SCIENCE,2019,7(1):409-418.
APA Zhang, Hao.,Chen, Yaodong.,Cai, Yunyu.,Liu, Jun.,Liu, Pengfei.,...&Liang, Changhao.(2019).Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer.BIOMATERIALS SCIENCE,7(1),409-418.
MLA Zhang, Hao,et al."Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer".BIOMATERIALS SCIENCE 7.1(2019):409-418.
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