Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Is level of acetylation directly correlated to radiation sensitivity of cancer cell? | |
Zhang, Fengqiu1,2,3; Chen, Zhu1,3; Shao, Changsheng1,3; Huang, Qing1,3 | |
2019 | |
发表期刊 | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS |
ISSN | 0027-5107 |
摘要 | It is known that histone deacetylase inhibitors (HDACis) can modify acetylation of tumor cells and affect radiation sensitivity, or, radiosensitivity. While previous studies showed that trichostatin A (TSA, a typical HDACi) could enhance cell acetylation and so be used as radiation-sensitizer in radiotherapy, we questioned if the radiosensitivity is correlated with cellular acetylation directly. So we inspected radiation response of HeLa cells treated with TSA and investigated the time-dependent effect on radiosensitivity. To our surprise, HeLa cells treated with 200 nM TSA for shorter period (6 h) had relatively higher acetylation level but apparently less radiation damage compared to the irradiated cells with same radiation dose treatment of TSA but for longer time (24 h) with lower acetylation level, gainsaying the direct relationship between acetylation and radiosensitivity. We explained that the anti-oxidation activity for the combined treatments with TSA-radiation gave rise to the enhanced radiation protection of the cells at certain period of time. This work has therefore for the first time presented the experimental evidence showing that there is no direct relationship between acetylation and radiation sensitivity, and our results may also provide the guidance for optimized radiotherapy assisted by HDACis in cancer treatment. |
关键词 | Acetylation Radiosensitivity HeLa cells Histone deacetylase inhibitors (HDACis) Trichostatin A (TSA) |
DOI | 10.1016/j.mrfmmm.2018.11.001 |
关键词[WOS] | HISTONE-DEACETYLASE INHIBITOR ; DNA-DAMAGE ; COMET-ASSAY ; GEL-ELECTROPHORESIS ; ANTIOXIDANT ENZYMES ; CARCINOMA-CELLS ; IN-VITRO ; TRICHOSTATIN ; RADIOSENSITIVITY ; EXPRESSION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[11475217] ; National Natural Science Foundation of China[11704343] ; Key research Project of College of henan Province[18A180032] |
项目资助者 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology |
WOS记录号 | WOS:000455475900002 |
出版者 | ELSEVIER SCIENCE BV |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/41331 |
专题 | 中科院强磁场科学中心 |
通讯作者 | Huang, Qing |
作者单位 | 1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Inst Tech Biol & Agr Engn, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 2.Zhengzhou Univ, Sch Phys Engn, Henan Key Lab Ion Beam Bioengn, Zhengzhou 450052, Henan, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Fengqiu,Chen, Zhu,Shao, Changsheng,et al. Is level of acetylation directly correlated to radiation sensitivity of cancer cell?[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2019,813(无):13-19. |
APA | Zhang, Fengqiu,Chen, Zhu,Shao, Changsheng,&Huang, Qing.(2019).Is level of acetylation directly correlated to radiation sensitivity of cancer cell?.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,813(无),13-19. |
MLA | Zhang, Fengqiu,et al."Is level of acetylation directly correlated to radiation sensitivity of cancer cell?".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 813.无(2019):13-19. |
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