Knowledge Management System of Hefei Institute of Physical Science,CAS
Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish | |
Yang, Wenbin1,2; Meng, Yutong1,2; Li, Danyang1,2; Wen, Quan1,2,3 | |
2019-01-24 | |
发表期刊 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE |
ISSN | 1662-5153 |
摘要 | The larval zebrafish is a promising vertebrate model organism to study neural mechanisms underlying learning and memory due to its small brain and rich behavioral repertoire. Here, we report on a high-throughput operant conditioning system for zebrafish larvae, which can simultaneously train 12 fish to associate a visual conditioned pattern with electroshocks. We find that the learning responses can be enhanced by the visual contrast, not the spatial features of the conditioned patterns, highlighted by several behavioral metrics. By further characterizing the learning curves as well as memory extinction, we demonstrate that the percentage of learners and the memory length increase as the conditioned pattern becomes darker. Finally, little difference in operant learning responses was found between AB wild-type fish and elavl3:H2B-GCaMP6f transgenic fish. |
关键词 | zebrafish larvae behavioral neuroscience learning vision high-throughput imaging automated image analysis |
DOI | 10.3389/fnbeh.2019.00004 |
关键词[WOS] | BEHAVIOR ; DOPAMINE ; INFORMATION ; MECHANISMS ; DEPENDENCE ; RESOLUTION ; PATTERNS ; HABENULA ; NEURONS ; MEMORY |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Science Foundation of China[NSFC-31471051] ; National Science Foundation of China[NSFC-91632102] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB10] |
项目资助者 | National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000456737700001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/41633 |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Yang, Wenbin; Wen, Quan |
作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Ctr Integrat Imaging, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab Brain Funct & Dis, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Wenbin,Meng, Yutong,Li, Danyang,et al. Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2019,13(无):13. |
APA | Yang, Wenbin,Meng, Yutong,Li, Danyang,&Wen, Quan.(2019).Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,13(无),13. |
MLA | Yang, Wenbin,et al."Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 13.无(2019):13. |
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