Institutional Repository of Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, People's Republic of China
The Role of Endoplasmic Reticulum in Introducing Nano-toxicology and The Mechanism Involved | |
Wang Juan1,2,3; Xu Wen-Juan4; Wang Xin-Wen4; Wang Jing-Jing1,2,3; Wang Mei-Mei4; Xu An1,2,5 | |
2019 | |
发表期刊 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS |
ISSN | 1000-3282 |
摘要 | With the wide application of nanomaterials in many fields such as food, drug and biomedicine, their negative impacts on the health of human beings in the process of production and uses have attracted much attention. Endoplasmic reticulum (ER), an important organelle and functions in folding and assembling of cellular proteins, synthesis of lipids, and storage of free calcium, is sensitive to stress. ER as one of the most sensitive targets of nanomaterials plays important roles in the toxicity of nanomaterials. This review summarizes the recent studies on the role of ER in the nanotoxicology of several typical nanomaterials, including silver nanoparticles (Ag-NPs), titanium dioxide nanoparticles (TiO2-NPs), zinc oxide nanoparticles (ZnO-NPs), gold nanoparticles (Au-NPs), silica nanoparticles (SiO2-NPs), fullerene, single/multi-walled carbon nanotubes (SWCNTs/MWCNTs) and grapheme/grapheme oxide (GO), and analyzes the difference. The nanomaterials can cause ER stress, and in turn induce apoptosis, inflammation and autophagy. They can also activate the release of Ca2+ from the ER Ca2+ stores through IP3 pathway and further trigger calcium-regulated apoptotic cell death. Nanomaterials tend to accumulate in ER causing damage of ER and inducing ER autophagy. |
关键词 | endoplasmic reticulum nanomaterials apoptosis inflammation autophagy toxicity |
DOI | 10.16476/j.pibb.2018.0052 |
关键词[WOS] | ZINC-OXIDE NANOPARTICLES ; TITANIUM-DIOXIDE NANOPARTICLES ; STRESS SIGNALING PATHWAY ; SILVER NANOPARTICLES ; GOLD NANOPARTICLES ; SILICA NANOPARTICLES ; AUTOPHAGOSOME FORMATION ; OXIDATIVE STRESS ; CELLULAR UPTAKE ; GRAPHENE OXIDE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[21677147] ; National Natural Science Foundation of China[21507002] ; National Natural Science Foundation of China[21607157] ; National Natural Science Foundation of China[21507136] ; China Postdoctoral Science Foundation[2016M600477] ; Anhui Province Postdoctoral Science Foundation[2017B161] ; National Training Program of Innovation for Undergraduates[201710366002] ; CAS Training Program of Innovation for Undergraduates ; Anhui Medical University[XJ201506] |
项目资助者 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; Anhui Province Postdoctoral Science Foundation ; 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WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
WOS记录号 | WOS:000457065800003 |
出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/41636 |
专题 | 技术生物与农业工程研究所 |
通讯作者 | Wang Mei-Mei; Xu An |
作者单位 | 1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Environm Toxicol & Pollut Control Technol, Inst Tech Biol & Agr Engn, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Anhui Med Univ, Dept Pathophysiol, Hefei 230032, Anhui, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Wang Juan,Xu Wen-Juan,Wang Xin-Wen,et al. The Role of Endoplasmic Reticulum in Introducing Nano-toxicology and The Mechanism Involved[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(1):20-31. |
APA | Wang Juan,Xu Wen-Juan,Wang Xin-Wen,Wang Jing-Jing,Wang Mei-Mei,&Xu An.(2019).The Role of Endoplasmic Reticulum in Introducing Nano-toxicology and The Mechanism Involved.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(1),20-31. |
MLA | Wang Juan,et al."The Role of Endoplasmic Reticulum in Introducing Nano-toxicology and The Mechanism Involved".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.1(2019):20-31. |
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