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A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy
Sun, Xiao1; Zhang, Guilong1; Du, Ruohong4; Xu, Rui2; Zhu, Dongwang3; Qian, Junchao5; Bai, Guo3; Yang, Chi3; Zhang, Zhiyuan3; Zhang, Xin6; Zou, Duohong2,3; Wu, Zhengyan1
2019-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Abstract

In this work, a tumor microenvironment (TME)-responsive biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging (MRI)-guided combinatorial cancer therapy was constructed. Fe3O4 nanoparticles decorated on the surface of MnSiO3 could effectively obstruct the pores of MnSiO3 and reduce the leakage of anticancer drugs under physiological conditions. The structure of the nanoplatform was broken under the weakly acidic and high-concentration glutathione conditions in the TME, resulting in the separation of the Fe3O4 nanoparticles from the nanoplatform and rapid drug release. In addition, the exfoliated Fe3O4 and released Mn2+ can help reduce the interference between their T-1 and T-2 contrast abilities, resulting in dual-mode MRI contrast enhancement. Furthermore, during the exfoliation process of the Fe3O4 nanocrystals, the catalytic activity of the Fe3O4 nanocrystals toward a Fenton-like reaction within cancer cells could be improved because of the increase in specific surface area, which led to the generation of highly toxic hydroxyl radicals and induced HeLa cell apoptosis. The nanoplatform also displayed excellent T-1-T-2 dual-mode MRI contrast enhancement and anticancer activity in vivo with reduced systemic toxicity. Thus, this multifunctional nanoplatform could be a potential nanotheranostic for dual-mode MRI-guided combinatorial cancer therapy.

KeywordMicroenvironment-responsive Degradable Combinatorial therapy Magnetic resonance imaging Nanotheranostics
DOI10.1016/j.biomaterials.2018.12.004
WOS KeywordTUMOR ACCUMULATION ; CONTRAST AGENTS ; NANOPARTICLES ; NANOMATERIALS ; DELIVERY ; SIZE ; SUPERSTRUCTURES ; THERANOSTICS ; PENETRATION ; VIVO
Indexed BySCI
Language英语
Funding ProjectYouth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province, China[17030701051] ; Natural Science Foundation of Anhui Province, China[1808085MB38] ; National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[31870969] ; National Natural Science Foundation of China[81801039] ; Anhui Science and Technology Plan Project[1604a0802082] ; Anhui Science and Technology Plan Project[1401045013] ; Anhui Province Funds for Distinguished Young Scientists[1508085J08] ; Key Projects of the Outstanding Young Talents in Colleges and Universities[gxyqZD2016058] ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine[shkw2017]
Funding OrganizationYouth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000457504900014
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/41895
Collection技术生物与农业工程研究所
Corresponding AuthorZou, Duohong; Wu, Zhengyan
Affiliation1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
2.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China
3.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Stomatol, Peoples Hosp 9, Dept Oral Surg,Sch Med,Shanghai Key Lab Stomatol, Shanghai 200001, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Stomatol, Hefei 230022, Anhui, Peoples R China
5.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei Canc Hosp, Hefei 230031, Anhui, Peoples R China
6.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xiao,Zhang, Guilong,Du, Ruohong,et al. A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy[J]. BIOMATERIALS,2019,194(无):151-160.
APA Sun, Xiao.,Zhang, Guilong.,Du, Ruohong.,Xu, Rui.,Zhu, Dongwang.,...&Wu, Zhengyan.(2019).A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy.BIOMATERIALS,194(无),151-160.
MLA Sun, Xiao,et al."A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy".BIOMATERIALS 194.无(2019):151-160.
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