Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy | |
Wang, Hui1,2; Mu, Qingxin1; Wang, Kui1; Revia, Richard A.1; Yen, Charles1; Gu, Xinyu3; Tian, Bowei4; Liu, Jun1; Zhang, Miqin1 | |
2019-03-01 | |
发表期刊 | APPLIED MATERIALS TODAY |
ISSN | 2352-9407 |
摘要 | Fluorescence imaging of biological systems in the second near-infrared window (NIR-II) has recently drawn much attention because of its negligible background noise of autofluorescence and low tissue scattering. Here we present a new NIR-II fluorescent agent, graphene quantum dots dual-doped with both nitrogen and boron (N-B-GQDs). N-B-GQDs have an ultra-small size (similar to 5 nm), are highly stable in serum, and demonstrate a peak fluorescent emission at 1000 nm and high photostability. In addition to the NIR-II imaging capability, N-B-GQDs efficiently absorb and convert NIR light into heat when irradiated by an external NIR source, demonstrating a photothermal therapeutic effect that kills cancer cells in vitro and completely suppresses tumor growth in a glioma xenograft mouse model. N-B-GQDs demonstrate a safe profile, prolonged blood half-life, and rapid excretion in mice, which are the characteristics favorable for in vivo biomedical applications. (C) 2018 Elsevier Ltd. All rights reserved. |
关键词 | Theranostic nanoparticle NIR II fluorescence imaging Graphene quantum dot Photothermal effect Cancer therapy |
DOI | 10.1016/j.apmt.2018.11.011 |
关键词[WOS] | CARBON NANOTUBES ; PHOTOLUMINESCENCE PROPERTIES ; FLUORESCENT ; FLUOROPHORES ; EMISSION ; SKIN |
收录类别 | SCI |
语种 | 英语 |
资助项目 | NIH[S10 OD016240] ; NIH[R031CA161953] |
项目资助者 | NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH |
WOS研究方向 | Materials Science |
WOS类目 | Materials Science, Multidisciplinary |
WOS记录号 | WOS:000458430900012 |
出版者 | ELSEVIER SCIENCE BV |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/42160 |
专题 | 中科院强磁场科学中心 |
通讯作者 | Zhang, Miqin |
作者单位 | 1.Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 3.Univ Washington, Dept Biochem, Seattle, WA 98195 USA 4.Univ Washington, Dept Appl Math, Seattle, WA 98195 USA |
推荐引用方式 GB/T 7714 | Wang, Hui,Mu, Qingxin,Wang, Kui,et al. Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy[J]. APPLIED MATERIALS TODAY,2019,14(无):108-117. |
APA | Wang, Hui.,Mu, Qingxin.,Wang, Kui.,Revia, Richard A..,Yen, Charles.,...&Zhang, Miqin.(2019).Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy.APPLIED MATERIALS TODAY,14(无),108-117. |
MLA | Wang, Hui,et al."Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy".APPLIED MATERIALS TODAY 14.无(2019):108-117. |
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