Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters

doi:10.1016/j.cej.2018.11.219

	Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters
	Si, Yuanchun 1,4; Zhang, Guilong 3; Wang, Dan 4; Zhang, Cheng 2; Yang, Chi 1; Bai, Guo 1; Qian, Junchao5 ; Chen, Qiaoer 4; Zhang, Zhiyuan 1; Wu, Zhengyan3 ; Xu, Yunsheng 2; Zou, Duohong 1
	2019-03-15
发表期刊	CHEMICAL ENGINEERING JOURNAL
ISSN	1385-8947
通讯作者	Xu, Yunsheng(xuyunsheng1018@163.com) ; Zou, Duohong(zouduohong@126.com)
摘要	Rational structure design benefits the development of new classes of contrast agents (CAs) with excellent magnetic resonance imaging performance. In this work, hydrogenated silica with a net nanostructure (HSiO2) was fabricated and used to modify gadolinium-doped iron oxide nanoclusters (GdIONCs) to form a core-shell nanoplatform (HSiO2@GdIONC) with enhanced T-1 and T-2 contrast ability. In this nanoplatform, the HSiO2 shell showed a strong binding capacity for water molecules because of the presence of hydrogen bonds, oxygen vacancies, and high specific surface areas, and the strong binding capacity significantly improved the spin-spin (T-2) and spin-lattice (T-1) imaging of the GdIONC core. In addition, the T-1 relaxation rate of the GdIONC core dramatically increased from 30.8 mM(-1) s(-1) to 38.2mM(-1) s(-1) after being coated with the HSiO2 shell, and the r(2) to r(1) ratio decreased from 10.9 to 8.3, which is an appropriate ratio (r(2)/r(1): 5-10) for dual-mode contrast. Cell and animal experiments suggested that HSiO2@GdIONC exhibited a better T-1- and T-2-weighted MR imaging effect than the bare GdIONC core, confirming that this strategy for modifying GdIONCs is a beneficial and promising approach for obtaining highly efficient dual-mode CAs.
关键词	Magnetic resonance imaging Water molecules Hydrogen bond Oxygen vacancy Contrast enhancement
DOI	10.1016/j.cej.2018.11.219
关键词[WOS]	FE3O4 NANOPARTICLES ; AGENTS ; T-1 ; THERAPY ; SURFACE ; SIZE
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[81771531] ; National Natural Science Foundation of China[81571395] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province[17030701051] ; Natural Science Foundation of Anhui Province[1808085MB38]
项目资助者	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province
WOS研究方向	Engineering
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS记录号	WOS:000460964000031
出版者	ELSEVIER SCIENCE SA
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/42424
专题	技术生物与农业工程研究所
通讯作者	Xu, Yunsheng; Zou, Duohong
作者单位	1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral Surg, Natl Clin Res Ctr Stomatol,Sch Med,Shanghai Key L, Shanghai 200001, Peoples R China 2.Wenzhou Med Univ, Dept Dermatovenereol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 4.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Si, Yuanchun,Zhang, Guilong,Wang, Dan,et al. Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters[J]. CHEMICAL ENGINEERING JOURNAL,2019,360:289-298.
APA	Si, Yuanchun.,Zhang, Guilong.,Wang, Dan.,Zhang, Cheng.,Yang, Chi.,...&Zou, Duohong.(2019).Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters.CHEMICAL ENGINEERING JOURNAL,360,289-298.
MLA	Si, Yuanchun,et al."Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters".CHEMICAL ENGINEERING JOURNAL 360(2019):289-298.