HFCAS OpenIR  > 中科院固体物理研究所
Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics
Xu, Rui1,3,4; Xu, Zhaowei3; Si, Yuanchun4; Xing, Xin4; Li, Qingdong2,3; Xiao, Jianmin2; Wang, Bin3; Tian, Geng3; Zhu, Ling1; Wu, Zhengyan2; Zhang, Guilong3
2020-08-19
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Corresponding AuthorZhu, Ling(zhuling1425@163.com) ; Wu, Zhengyan(zywu@ipp.ac.cn) ; Zhang, Guilong(glzhang@bzmc.edu.cn)
AbstractThis work finds that Fe3O4 nanoclusters can rearrange by Gd doping and then self-assemble to a hollow magnetic nanocluster (HMNC), providing larger magnetic moments to obtain an excellent MRI capability and increasing the number of oxygen vacancies in HMNC. The hollow structure makes platinum(IV) prodrugs effectively load into HIVING. Second, plenty of oxygen vacancy defects can capture oxygen molecules, enhance the catalytic activity of HMNC, and then promote intracellular ROS generation. On the basis of this, a targeting iRGD-labeled HMNC nanosystem (iHMNCPt-O-2) is developed through loading oxygen molecules and platinum(IV) prodrugs for chemo- and chemodynamic therapy of cancer. This nanosystem shows an excellent response ability to weak acid and GSH, which can cause a series of cascade reactions in a cell. These cascade reactions are dramatically enhanced at the intracellular ROS level, cause mitochondria and DNA damage, and then induce cancer cell death. Besides, systemic delivery of iHMNCPt-O-2 significantly enhanced the MRI contrast signal of tumors and improved the quality of MR images, accurately diagnosing tumors. Therefore, this work provides a novel method for accelerating the Fenton-like reaction and enhancing the MRI capability and fabricates a promising "all-in-one" system to overwhelm the problems of cancer theranostic.
Keywordoxygen vacancy defects nanotheranostic agent catalytic activity MRI contrast enhancement oxygen self-supplement
DOI10.1021/acsami.0c09952
WOS KeywordOVERCOME MULTIDRUG-RESISTANCE ; FENTON-LIKE DEGRADATION ; CHEMOTHERAPY ; GLUTATHIONE ; GENERATION ; MICROENVIRONMENT ; NANOPARTICLES ; THERAPY ; DAMAGE
Indexed BySCI
Language英语
Funding ProjectTaishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; National Natural Science Foundation of China[81630019] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
Funding OrganizationTaishan Scholars Construction Engineering ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000563074900010
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/43057
Collection中科院固体物理研究所
Corresponding AuthorZhu, Ling; Wu, Zhengyan; Zhang, Guilong
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Dept Radiol, Shanghai Peoples Hosp 9, Shanghai 200001, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai 264003, Peoples R China
4.Anhui Med Univ, Dept Dent Implant Ctr, Stomatol Hosp & Coll, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China
Recommended Citation
GB/T 7714
Xu, Rui,Xu, Zhaowei,Si, Yuanchun,et al. Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12.
APA Xu, Rui.,Xu, Zhaowei.,Si, Yuanchun.,Xing, Xin.,Li, Qingdong.,...&Zhang, Guilong.(2020).Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,12.
MLA Xu, Rui,et al."Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 12(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, Rui]'s Articles
[Xu, Zhaowei]'s Articles
[Si, Yuanchun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, Rui]'s Articles
[Xu, Zhaowei]'s Articles
[Si, Yuanchun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, Rui]'s Articles
[Xu, Zhaowei]'s Articles
[Si, Yuanchun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.