Institutional Repository of Chinese Acad Sci, High Field Magnet Lab,Hefei 230031, Anhui, Peoples R China
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway | |
Ma, Xiaoyu; Wang, Lin; Huang, De; Li, Yunyan; Yang, Dongdong; Li, Tingting; Li, Fudong; Sun, Linchong; Wei, Haoran; He, Kun; Yu, Fazhi; Zhao, Debiao; Hu, Lan; Xing, Songge; Liu, Zhaoji; Li, Kui; Guo, Jing; Yang, Zhenye; Pan, Xin; Li, Ailing; Shi, Yunyu; Wang, Junfeng; Gao, Ping; Zhang, Huafeng | |
2017-11-15 | |
发表期刊 | Nature Communications |
摘要 | Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to optimize the growth advantage for cancer cells are still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP). We find that Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By activating G6PD through promoting the formation of its active dimer, Plk1 increases PPP flux and directs |
学科门类 | 理学::生物学 |
DOI | 10.1038/s41467-017-01647-5 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/43276 |
专题 | 中科院强磁场科学中心 |
作者单位 | 1.Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of China, Hefei 230027, Ch 2.High Magnetic Field Laboratory, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei, Anhui 230031, China 3.Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. 4.Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, 100850, China. |
推荐引用方式 GB/T 7714 | Ma, Xiaoyu,Wang, Lin,Huang, De,et al. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway[J]. Nature Communications,2017. |
APA | Ma, Xiaoyu.,Wang, Lin.,Huang, De.,Li, Yunyan.,Yang, Dongdong.,...&Zhang, Huafeng.(2017).Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.Nature Communications. |
MLA | Ma, Xiaoyu,et al."Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway".Nature Communications (2017). |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Polo-like kinase 1 c(1933KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论