Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck

doi:10.7150/ijbs.47068

HFCAS OpenIR

	Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck
	Xu, Qiang 1,2; Fang, Meiyu 2,3; Zhu, Jing 2,4; Dong, Haoru 5; Cao, Jun 2,3; Yan, Lin 6; Leonard, Fransisca 7; Oppel, Felix 8; Sudhoff, Holger 8; Kaufmann, Andreas M.9,10,11,12; Albers, Andreas E.10,11,12,13; Qian, Xu 2,4
	2020
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
通讯作者	Qian, Xu(qian_michelle2014@163.com)
摘要	Immunotherapies such as immune checkpoint blockade benefit only a portion of patients with head and neck squamous cell carcinoma. The multidisciplinary field of nanomedicine is emerging as a promising strategy to achieve maximal anti-tumor effect in cancer immunotherapy and to turn non-responders into responders. Various methods have been developed to deliver therapeutic agents that can overcome bio-barriers, improve therapeutic delivery into the tumor and lymphoid tissues and reduce adverse effects in normal tissues. Additional modification strategies also have been employed to improve targeting and boost cytotoxic T cell-based immune responses. Here, we review the state-of-the-art use of nanotechnologies in the laboratory, in advanced preclinical phases as well as those running through clinical trials assessing their advantages and challenges.
关键词	nanotherapeutics drug delivery cancer immunotherapy nanovaccine head and neck squamous cell carcinoma human papillomavirus
DOI	10.7150/ijbs.47068
关键词[WOS]	NANOPARTICLE VACCINE ; NAB-PACLITAXEL ; OPEN-LABEL ; CANCER ; DELIVERY ; EFFICACY ; PEPTIDE ; POTENT ; DNA ; CISPLATIN
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81702091] ; Medical and the Health Science Project of Zhejiang Province[2019KY327] ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital
项目资助者	National Natural Science Foundation of China ; Medical and the Health Science Project of Zhejiang Province ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS类目	Biochemistry & Molecular Biology ; Biology
WOS记录号	WOS:000555111400003
出版者	IVYSPRING INT PUBL
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/45143
专题	中国科学院合肥物质科学研究院
通讯作者	Qian, Xu
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Lab, Hangzhou, Peoples R China 5.Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Peoples R China 6.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 7.Houston Methodist Res Inst, Dept Nanomed, Houston, TX USA 8.Klinikum Bielefeld, Dept Otolaryngol Head & Neck Surg, Bielefeld, Germany 9.Charite Univ Med Berlin, Clin Gynecol, Berlin, Germany 10.Free Univ Berlin, Berlin, Germany 11.Humboldt Univ, Berlin, Germany 12.Berlin Inst Hlth, Berlin, Germany 13.Charite Univ Med Berlin, Dept Otolaryngol Head & Neck Surg, Berlin, Germany
推荐引用方式 GB/T 7714	Xu, Qiang,Fang, Meiyu,Zhu, Jing,et al. Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2020,16.
APA	Xu, Qiang.,Fang, Meiyu.,Zhu, Jing.,Dong, Haoru.,Cao, Jun.,...&Qian, Xu.(2020).Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,16.
MLA	Xu, Qiang,et al."Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 16(2020).