Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window

doi:10.1002/smll.202001177

HFCAS OpenIR

	Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window
	Zhang, Ya 1; Wang, Yingjie 2; Yang, Xueqin 1; Yang, Qinglai 1; Li, Juan 1,2; Tan, Weihong 1,3,4
	2020-08-06
发表期刊	SMALL
ISSN	1613-6810
通讯作者	Yang, Qinglai(qingyu513@126.com) ; Li, Juan(lijuan@fzu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
摘要	Photoacoustic imaging-guided photothermal therapy in the second near-infrared (NIR-II) window shows promise for clinical deep-penetrating tumor phototheranostics. However, ideal photothermal agents in the NIR-II window are still rare. Here, the emeraldine salt of polyaniline (PANI-ES), especially synthesized by a one-pot enzymatic reaction on sodium bis(2-ethylhexyl) sulfosuccinate (AOT) vesicle surface (PANI-ES@AOT, lambda(max) approximate to 1000 nm), exhibits excellent dispersion in physiological environment and remarkable photothermal ability at pH 6.5 (photothermal conversion efficiency of 43.9%). As a consequence of the enhanced permeability and retention effect of tumors and the doping-induced photothermal effect of PANI-ES@AOT, this pH-sensitive NIR-II photothermal agent allows tumor acidity phototheranostics with minimized pseudosignal readout and subdued normal tissue damage. Moreover, the enhanced fluidity of vesicle membrane triggered by heating is beneficial for drug release and allows precise synergistic therapy for an improved therapeutic effect. This study highlights the potential of template-oriented (or interface-confined) enzymatic polymerization reactions for the construction of conjugated polymers with desired biomedical applications.
关键词	enzymatic polymerization photoacoustic imaging photothermal-chemo synergistic therapy polyaniline second near-infrared window
DOI	10.1002/smll.202001177
关键词[WOS]	AOT VESICLES ; POLYMERIZATION ; NANOPARTICLES
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[91959102] ; Natural Science Foundation of Fujian Province of China[2017J06004] ; Shanghai Rising-Star Program[19QA1405400]
项目资助者	National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province of China ; Shanghai Rising-Star Program
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000555957400001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/45159
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Qinglai; Li, Juan; Tan, Weihong
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp,Coll Chem & Chem, Inst Mol Med IMM,State Key Lab Oncogenes & Relate, Shanghai 200240, Peoples R China 2.Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm,MO, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Fuzhou 350108, Peoples R China 3.Hunan Univ, Aptamer Engn Ctr Hunan Prov, Coll Biol,Mol Sci & Biomed Lab MBL, Coll Chem & Chem Engn,State Key Lab Chemo Biosens, Changsha 410082, Hunan, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ya,Wang, Yingjie,Yang, Xueqin,et al. Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window[J]. SMALL,2020.
APA	Zhang, Ya,Wang, Yingjie,Yang, Xueqin,Yang, Qinglai,Li, Juan,&Tan, Weihong.(2020).Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window.SMALL.
MLA	Zhang, Ya,et al."Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window".SMALL (2020).